Thiol/Disulphide Homeostasis in Unexplained Infertility

NCT05628766 | Completed

• 1 other identifier: SiirtUNIVERSI
• Study Type: observational
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

The aim in this study is to determine whether there is a relationship between Thiol / Disulphide levels in primary infertile patients and comparing them with infertile patients and the control group. For this purpose, 41 women followed up with the diagnosis of primary infertility in Siirt Training and Research Hospital between November 2022 and January 2023 will be included in the study. The same number of (n:41) non-infertile control women will be included. Age, pregnancy history and medical history of both groups will be recorded. FSH, LH, E2, TSH, and prolactin levels taken routinely in these patients will be examined. Thiol/disulphide levels in the blood will be checked by taking whole blood from these patients. In the light of the information thus obtained, the investigator plan to determine whether there is a relationship between oxidant/antioxidant balance in primary infertile patients.

Conditions

Oxidative Stress; Infertility; Antioxidative Stress

Outcome Measures

Primary Outcomes (1)

• Measuring the total oxidant/antioxidant load with the Thiol/disulfide method in patients with unexplained infertility

  To determine whether there is a relationship between oxidant/ antioxidant balance in primary infertile patients by looking at Thiol/disulphide blood levels in both groups.

  "through study completion, an average of 4 months

Study Arms (2)

Women diagnosed with primary infertility (n:41)

Women which followed up with infertility of unknown cause.

Other: complete blood count

Control group ( n:41)

Healthy women who are not infertile

Other: complete blood count

Interventions

complete blood count OTHER

Thiol/disulphide levels in the blood will be checked by taking complete blood count

Control group ( n:41); Women diagnosed with primary infertility (n:41)

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women between the age of 18-35 diagnosed with infertility of unknown cause.

You may qualify if:

• Patients diagnosed with primary infertility
• Patients between the age of 18-35

You may not qualify if:

• Active hypertension
• Chronic liver or kidney failure history
• Coronary artery disease
• Acute infection (within 14 days)
• Any chronic inflammatory disease
• Presence of autoimmune disease
• Known malignancy
• Inflammatory bowel disease
• Hormonal contraception
• Smoking
• alcohol use
• Drug use
• Patients with tubal infertility
• Partner with abnormal spermiogram

Sponsors & Collaborators

• Siirt University: lead

Study Sites (1)

Siirt Üniversity Medical Faculty

Siirt, 56000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Infertility

Interventions

Blood Cell Count

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Cell Count; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Hematologic Tests; Investigative Techniques; Cell Physiological Phenomena; Blood Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Şerif Aksin, assoc.Prof

  Siirt University Medical Faculty Obstetrics and Gynecology Departmant

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: November 7, 2022
• First Posted: November 29, 2022
• Study Start: November 30, 2022
• Primary Completion: April 21, 2023
• Study Completion: April 21, 2023
• Last Updated: April 25, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)