An Adolescent Health and Wellbeing Check-up Programme in Three African Cities (Y-Check)
Y-Check
1 other identifier
interventional
6,000
3 countries
3
Brief Summary
This is a multi-country prospective intervention study, with a mixed-method process evaluation to assess the implementation, effects and short-term cost-effectiveness of Y-Check. The intervention involves screening, on-the-spot care and, if needed, referral of adolescents through health and wellbeing check-up visits in early adolescence (10-14 years) and older adolescence (15-19 years old). In each city, the intervention will be delivered to 2000 adolescents recruited in schools (both age groups) or community venues (older adolescents only).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2023
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2023
CompletedFirst Submitted
Initial submission to the registry
May 16, 2023
CompletedFirst Posted
Study publicly available on registry
October 19, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2024
CompletedOctober 19, 2023
October 1, 2023
1.3 years
May 16, 2023
October 12, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Y-Check Screening outcome
Proportion of those screening positive for at least one condition who receive appropriate on-the-spot care or complete appropriate referral for all identified conditions within 4 months (i.e. they attend a provider for referral care who has been accredited by the study team and has been shown to be capable of providing appropriate referral care).
16 weeks (4 months)
Secondary Outcomes (9)
Condition Screening outcome
16 weeks (4 months)
Previously untreated conditions identified (yield)
16 weeks (4 months)
Qualitative assessment of adolescents who find the intervention acceptable
16 weeks (4 months)
Qualitative assessment of teachers, parents and health workers who find the intervention acceptable
16 weeks (4 months)
Proportion of adolescents who take up and use Y-Check services and referrals
16 weeks (4 months)
- +4 more secondary outcomes
Study Arms (1)
No comparison group
OTHERIn our study sites, a contemporaneous comparison group is not required since no routine screening is currently taking place, and as a result, assessments at baseline will serve as the counterfactual for internal comparisons
Interventions
Y-Check is a novel intervention delivering a health check-up and where indicated will provide on-the-spot care and referral for common conditions on two occasions in adolescence (in young adolescents (10-14 year-olds) - soon after the onset of puberty - and again in older adolescents (15-19 year-olds) - when many adolescents become, or are soon to become, sexually active). It will also provide health promotion information and materials to support positive behaviours and healthy lifestyles during adolescence and beyond. Adolescents will only be screened for conditions that have an accurate, low-cost, acceptable screening test and a locally accessible, effective intervention. The conditions selected for screening will be chosen to reflect the local epidemiological contexts (e.g. screening for malaria will only take place in high malaria endemic areas).
HEEADSSS stands for Home, Education/Employment, Eating, Activities, Drugs, Sexuality, Suicide/Depression, and Safety (Klein et al., 2014) and Patients´ Health Questionnaire - Adolescent (PHQ-A), Generalised Anxiety Disorder (GAD-9) and counselling and referral where indicated
World Health Organization (WHO) ASSIST-Y tool (Humeniuk, 2016) and referral where indicated
HEEADSSS (Klein et al., 2014) and counselling and advice
MUAC (Middle Upper Arm Circumference), BMI (Body Mass Index) followed by Counselling and advice +/- referral where indicated
Hemocue. Iron and folic-acid supplementation (3 months supply) if anaemic. If severely anaemic (\<8g/dl) refer to health facility.
Questions on oral health and visual inspection followed by advice, gift of toothpaste and toothbrush, fluoride varnish application +/- Silver Diamine Fluoride application +/- referral
Question on circumcision status. Visual inspection. Referral for Voluntary Medical Male Circumcision) where uncircumcised (males only)
Question (s) on sexual activity and other risky behaviours, followed by Risk reduction counselling, Provision of condoms, Provision of modern contraceptives (emergency contraception, depot injections, oral contraceptive pill) (females only) PreExposure Prophylaxis (PrEP) (females only)
HIV oral mucosal self-test +/- confirmatory blood-based rapid diagnostic test followed by Counselling + referral to treatment where indicated
Chlamydia Trachomatic (CT) /Neisseria Gonorrhea (NG) test on urine sample, Trichomoniasis Vaginalis (TV) test and treatment where indicated
Question on Human Papilloma Virus (HPV) immunisation history. Review of vaccination card. Followed by referral to immunization
Peek Acuity or Snellen Tumbling-E and Refer to specialist if indicated
HearScreen smartphone app +/- HearTest plus Inspection for presence of wax and wax removal. Refer to specialist if indicated
Questions on physical impairment. Jump or squat test Functional reach test Referral to specialist if indicated
Questions on experience of convulsions followed by referral to specialist if indicated
Blood pressure measured using digital sphygmomanometer followed by counselling and advice if indicated
Eligibility Criteria
You may qualify if:
- To be included in the study, adolescents aged 10-19 must fall into one of the first three categories below and fulfil category 4.
- Be attending selected classes of Year 5 of primary school in Mwanza (median age 11 years); Grade 5/6 of primary school in Chitungwiza (median age 11 years); or Year 1 of Junior Secondary School in Cape Coast (median age 12 years) OR
- Be attending selected classes in Year 3 of Secondary School in Mwanza (median age 17 years), Form 3/4 in Chitungwiza (median age 17 years), or Year 2 of Senior Secondary School in Cape Coast (median age 16 years) OR
- Be resident in a selected community during the time of the Y-Check intervention, and be aged 16-19 years AND
- Have a completed and signed Informed Consent and have a signed Informed Assent Form if the adolescent is below the national age of consent or is seen in a school, irrespective of their age.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- World Health Organizationlead
- London School of Hygiene and Tropical Medicinecollaborator
- University of Ghanacollaborator
- Mwanza Intervention Trials Unitcollaborator
- Biomedical Research and Training Institutecollaborator
Study Sites (3)
Schools and Community Centers
Cape Coast, Ghana
Schools and community centers
Mwanza, Tanzania
Schools and community centers
Chitungwiza, Zimbabwe
Related Publications (1)
Banati P, Ross DA, Weobong B, Kapiga S, Weiss HA, Baltag V, Nzvere F, Glozah F, Nsanya MK, Greco G, Ferrand R, Doyle AM; Y-Check Research Programme Team. Adolescent health and well-being check-up programme in three African cities (Y-Check): protocol for a multimethod, prospective, hybrid implementation-effectiveness study. BMJ Open. 2024 Jun 21;14(6):e077533. doi: 10.1136/bmjopen-2023-077533.
PMID: 38908843DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Prerna Banati, PhD
World Health Organization
- PRINCIPAL INVESTIGATOR
Baltag Valentina, MD
World Health Organization
- PRINCIPAL INVESTIGATOR
Aoife Doyl, PhD
Biomedical Training and Research Institute
- PRINCIPAL INVESTIGATOR
Saidi Kapiga, MD
Mwanza Intervention Trials Unit
- PRINCIPAL INVESTIGATOR
Benedict Weobong, PhD
University of Ghana
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Scientist, Principal Investigator
Study Record Dates
First Submitted
May 16, 2023
First Posted
October 19, 2023
Study Start
March 1, 2023
Primary Completion
June 30, 2024
Study Completion
June 30, 2024
Last Updated
October 19, 2023
Record last verified: 2023-10
Data Sharing
- IPD Sharing
- Will not share