Micro-expressions in Patients With Prolonged Disorders of Consciousness

NCT06088628 | Recruiting

• 1 other identifier: Micro-expression
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the microexpressions in patients with prolonged disorders of consciousness. The main questions it aims to answer are:

• Inducing micro-expression changes in patients with prolonged disorders of consciousness through various emotional stimuli, and further to achieve precise classification of their levels of consciousness.
• Detecting micro-expressions in patients with prolonged disorders of consciousness to assist clinical diagnosis of levels of consciousness, e.g., complement the disgnosis of clinical scales such as CRS-r scale.
• By monitoring micro-expression changes in patients with prolonged disorders of consciousness, researchers can explore their residual brain function, thereby advancing research into relevant neural mechanisms. Participants will be subjected to consciousness assessment by CRS-r scale, and their micro-expression changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.

Conditions

Consciousness Disorders

Keywords

disorders of consciousness; consciousness disorders; microexpressions; emotional stimuli; consciousness

Outcome Measures

Primary Outcomes (2)

• GOSE score

  GOS-E is an extended version of the Glasgow Outcome Scale (GOS), which was developed to provide a more detailed assessment of patient functionality and quality of life after experiencing such an injury. It has eight categories: Dead, Vegetative State, Lower Severe Disability, Upper Severe Disability, Lower Moderate Disability, Upper Moderate Disability, Lower Good Recovery, and Upper Good Recovery

  six month

• CRS-r score

  CRS-R a standardized neurobehavioral assessment measure designed for use in patients with disorders of consciousness. The scale is intended to be used to establish diagnosis, monitor behavioral recovery, predict outcome, and assess treatment effectiveness. The CRS-R consists of 6 subscales designed to assess auditory function, receptive and expressive language, visuoperception, communication ability, motor functions, and arousal level.

  six month

Study Arms (2)

DoC patients

Patients with disorders of consciousness.

Diagnostic Test: Facial expression; Electroencephalogram; MRI

Healthy controls

Healthy participants matched by gender and age.

Diagnostic Test: Facial expression; Electroencephalogram; MRI

Interventions

Facial expression; Electroencephalogram; MRI DIAGNOSTIC_TEST

Recording facial expressions of participants, EEG recordings, and MRI scans.

DoC patients; Healthy controls

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients are recruited from both general hospitals and rehabilitation hospitals.

You may qualify if:

• Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
• Aged between 18 and 80 years;
• Stable vital signs;
• Voluntary participation of family members with signed informed consent;
• Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.

You may not qualify if:

• Locked-in syndrome;
• Contraindications for EEG examination;
• Contraindications for MRI scanning, such as the presence of internal metallic implants;
• Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.

Sponsors & Collaborators

• Hangzhou Mingzhou Brain Rehabilitation Hospital: collaborator
• Zhejiang Provincial People's Hospital: collaborator
• Zhejiang Provincial Armed Police Corps Hospital: collaborator
• First Affiliated Hospital of Zhejiang University: lead

Study Sites (1)

First Affiliated Hospital,Zhejiang University

Hangzhou, Zhejiang, 310003, China

RECRUITING

MeSH Terms

Conditions

Consciousness Disorders

Interventions

Electroencephalography; Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Tomography; Diagnostic Imaging

Study Officials

• Benyan Luo, Doctor

  Zhejiang University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fangping He, Master

CONTACT

86-13819114225; hefangping@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 29, 2023
• First Posted: October 18, 2023
• Study Start: September 27, 2022
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: January 14, 2026

Record last verified: 2025-11

Locations

CN (1)