Risk Markers of Arterial Aging. The Paris Prospective Study III-2

NCT06079424 | Recruiting

• 1 other identifier: C21-67
• Study Type: observational
• Target: 7,500
• Locations: 1 country
• Sites: 1

Brief Summary

The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.

Conditions

Arterial Stiffness

Keywords

risk factors; cohort; cardiovascular diseases

Outcome Measures

Primary Outcomes (10)

• carotid diameter

  high precision carotid echo tracking diameter in mm

  by 2027

• intima media thickness

  high precision echo tracking intima media thickness of the common carotid artery in mm

  by 2027

• carotid plaques

  high precision carotid echo tracking carotid plaques

  by 2027

• wall cross sectional area

  high precision carotid echo tracking carotid wall cross sectional area, mm2

  by 2027

• distensibility coefficient

  high precision carotid echo tracking distensibility coefficient in 10-3/kPa

  by 2027

• elastic modulus

  high precision carotid echo tracking Young's elastic modulus, 10-3\*kPa

  by 2027

• pulse wave velocity

  high precision carotid echotracking pulse wave velocity, m/s

  by 2027

• carotid wall stress

  high precision carotid echotracking circumferential wall stress in kPa

  by 2027

• stiffness

  high precision carotid echotracking Beta stiffness index

  by 2027

• pulse pressure

  high precision carotid echotracking pulse pressure in mmHg

  by 2027

Secondary Outcomes (10)

• brachial artery diameter

  by 2027

• thickness of the intima media of the radial artery

  by 2027

• arterial plaques

  by 2027

• wall cross sectional area of the radial artery

  by 2027

• distensibility of the radial artery

  by 2027

Study Arms (1)

Level of vascular aging

community-based prospective longitudinal cohort

Other: high-precision carotid echo-tracking

Interventions

high-precision carotid echo-tracking OTHER

evaluation of vascular aging parameters and baroreflex sensitivity

Level of vascular aging

Eligibility Criteria

• Age: 60 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Men and women aged 60 to 95 years who are participants of the PPS3 study and have accepted to undergo a second physical examination and answer to health questionnaires in primary care health centre in Paris that is subsidized by the French Health Insurance System.

You may qualify if:

• Being enrolled in PPS3 and having signed an informed consent for PPS3-2

You may not qualify if:

• Institutionalized participants
• Participants under guardianship
• Participants under judicial safeguard measure

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

Centre d'Investigation Précliniques

Paris, 75016, France

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

EDTA and citrate plasmatic samples

MeSH Terms

Conditions

Cardiovascular Diseases

Study Officials

• Jean-Philippe Empana, MD, PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jean-Philippe Empana, MD, PhD

CONTACT

33153988020; jean-philippe.empana@inserm.fr

Xavier Jouven, MD, PhD

CONTACT

xavier.jouven@inserm.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 26, 2023
• First Posted: October 12, 2023
• Study Start: June 20, 2025
• Primary Completion (Estimated): May 1, 2031
• Study Completion (Estimated): December 1, 2033
• Last Updated: September 11, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)