Augmented Velocity Index of Intra-abdominal, Carotid and Retinal Arteries

NCT05273905 | Unknown

• 1 other identifier: 2022.3.1
• Study Type: observational
• Target: 350
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background: Augmented Velocity Index (Avi) is a new Doppler index which can potentially be used to assess arterial stiffness. The Avi of common carotid artery is found to be associated with arterial stiffness and have initial correlation with cardiovascular risk factors. Avi can be used in any vessels (superficial or deep vessels) where arterial Doppler waveforms can be obtained. Aims: The aims of this study are to investigate the associations of Avi of hepatic artery, renal artery, central retinal artery and internal carotid artery with arterial stiffness and cardiovascular risk factors in a group of apparently normal subjects. Methods: Recruit 350 subjects with no known medical illness or drug treatment for ultrasound examinations and blood tests. In ultrasound examination, the Avi of carotid arteries, hepatic arteries, renal arteries and retinal arteries are recorded. The carotid-femoral pulse wave velocity is also calculated for the assessment of central aortic stiffness. Other important correlates of arterial stiffness including carotid intima-media thickness, fatty liver status, liver stiffness and abdominal fat thickness are assessed in the ultrasound examination. The clinical and laboratory examinations include anthropometric indexes, plasma glucose level, lipid profile, renal function tests, liver function test, urinary albumin creatinine ratio, blood pressure measurement.

Conditions

Arterial Stiffness

Outcome Measures

Primary Outcomes (1)

• Augmented Velocity Index (Avi)

  Avi of carotid, renal, hepatic and retinal arteries as recorded from the Doppler ultrasound waveforms of those arteries

  Aug 2022 - May 2024

Secondary Outcomes (1)

• Arterial wall thickness, liver stiffness and fatty liver status

  Aug 2022 - May 2024

Interventions

Ultrasound derived Avi DIAGNOSTIC_TEST

Assess the Avi of carotid arteries, hepatic arteries, renal arteries and central retinal arteries.

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Apparently healthy volunteers

You may qualify if:

• Apparently healthy volunteers

You may not qualify if:

• Subjects with known medical illnesses including cancer, stroke, cardiovascular disease, diabetes, hypertension, dyslipidaemia, peripheral vascular disease, gout, systemic lupus erythematosus, psoriasis, rheumatoid arthritis and thyrotoxicosis.
• Subjects with long term drug use

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Adjunct Associate Professor

Study Record Dates

• First Submitted: March 1, 2022
• First Posted: March 10, 2022
• Study Start: May 1, 2022
• Primary Completion: August 1, 2024
• Study Completion: March 1, 2025
• Last Updated: March 24, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share