Hypertension, Antihypertensive Medication Use, and Risk of Psoriasis

NCT06075394 | Completed

• 1 other identifier: xijingH-PF-202310
• Study Type: observational
• Target: 9,294
• Locations: 1 country
• Sites: 1

Brief Summary

The influences of hypertension and antihypertensive medication on psoriasis have been long discussed. Given the limited and inconsistent evidence available, there is a need to further explore and clarify the relationship between hypertension and psoriasis, as well as to assess the relationship between antihypertensive medication use and the development or worsening of psoriasis symptoms. The aim of this retrospective study was to analyze data from electronic health records in a large population-based cohort, and the investigators aimed to investigate whether there was a significant association between hypertension and the use of related antihypertensive medications, such as ACEis, and psoriasis, and to explore potential confounders that may influence this association. Understanding the potential relationship between antihypertensive medication and psoriasis is critical, as this may have implications for the management of hypertension in patients with psoriasis or those at risk of developing the condition. This study will contribute to the existing body of evidence and provide valuable insights for clinicians to make informed decisions about the use of antihypertensive medication in this patient population, ultimately contributing to more effective prevention and management strategies for individuals affected by these diseases.

Conditions

Psoriasis

Keywords

Hypertension; Antihypertensive Medication; Psoriasis

Outcome Measures

Primary Outcomes (1)

• Hypertension as a risk factor for psoriasis

  Hypertension has the potential to act as an underlying risk factor for the onset of psoriasis and has been identified as correlating with the frequency of recurrent psoriatic episodes.

  Information collection: over a span of 2 months

Secondary Outcomes (1)

• Antihypertensive Medication as a risk factor for psoriasis

  Information collection: over a span of 2 months

Study Arms (2)

psoriasis patients

Patients with psoriasis in the Department of Dermatology, Xijing Hospital of Air Force Medical University from December 2012 to December 2022 were consecutively collected. Inclusion criteria: (1) age ≥18 years; (2) Clear diagnosis of psoriasis. Exclusion criteria: (1) age \<18; (2) Hypertension caused by conditions such as primary hypertension, hyperthyroidism, chronic renal insufficiency, or Cushing's syndrome, which are severe endocrine system diseases; (3) Patients with autoimmune diseases, severe cardiovascular, hepatic, renal, or other major organ disorders, as well as blood disorders and endocrine system diseases.

Healthy individuals

Healthy individuals being randomly selected healthy individuals from a medical examination center.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The investigators conducted a retrospective cohort study of psoriasis patients (≥18 years old) admitted as inpatients of Xijing hospital. Prior to the commencement of the survey, the investigators underwent collective training on data collection procedures to ensure the quality and reliability of the data. The study population included psoriasis patients aged 18 years or older who had been hospitalized at least once between 2012 and December 2022. Healthy individuals being randomly selected healthy individuals from a medical examination center.

You may qualify if:

• Age ≥18 years;
• Clear diagnosis of psoriasis

You may not qualify if:

• Age \<18;
• Hypertension caused by conditions such as primary hypertension, hyperthyroidism, chronic renal insufficiency, or Cushing's syndrome, which are severe endocrine system diseases;
• Patients with autoimmune diseases, severe cardiovascular, hepatic, renal, or other major organ disorders, as well as blood disorders and endocrine system diseases.

Sponsors & Collaborators

• Xijing Hospital: lead

Study Sites (1)

Dermatology Derpartment of Xijing Hospital

Xi'an, Shaanxi, 710032, China

Location

MeSH Terms

Conditions

Psoriasis; Hypertension

Condition Hierarchy (Ancestors)

Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: chief of dermatology

Study Record Dates

• First Submitted: October 3, 2023
• First Posted: October 10, 2023
• Study Start: November 1, 2021
• Primary Completion: June 1, 2022
• Study Completion: October 1, 2023
• Last Updated: October 12, 2023

Record last verified: 2023-10

Locations

CN (1)