Prediction Model for Osteopenia in Patients With Psoriasis

NCT07112755 | Completed

• 1 other identifier: S2022-196-01-01
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to develop a clinical prediction model for osteopenia in patients with psoriasis. By retrospectively analyzing demographic, laboratory, and lifestyle variables, the investigators will identify risk factors associated with decreased bone mineral density (BMD) in this population. The study will facilitate the identification of high-risk individuals and provide evidence for early screening and intervention strategies.

Conditions

Psoriasis

Keywords

psoriasis; osteopenia

Outcome Measures

Primary Outcomes (1)

• Occurrence of Osteopenia in Patients With Psoriasis

  Bone mineral density (BMD) will be assessed using dual-energy X-ray absorptiometry (DEXA) at the lumbar spine and/or femoral neck. Osteopenia is defined as a T-score between -1.0 and -2.5 according to WHO criteria. Patients will be categorized accordingly.

  At the time of DEXA assessment during enrollment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed with plaque psoriasis who attended the Department of Dermatology at the First Medical Center of the PLA General Hospital. Eligible participants were aged 18 years or older and underwent bone mineral density assessment by DEXA. Patients with significant comorbidities affecting bone metabolism were excluded.

You may qualify if:

• Diagnosis of plaque psoriasis according to established diagnostic criteria
• Age ≥ 18 years
• Willingness to participate in the study and provide written informed consent

You may not qualify if:

• Severe hepatic or renal dysfunction
• Coexisting immune, endocrine, or malignant diseases that may affect bone metabolism
• Congenital joint deformities, history of joint trauma, or joint replacement surgery
• Use of systemic corticosteroids, calcium supplements, or bisphosphonates within the past 3 months
• Psychiatric or psychological disorders

Sponsors & Collaborators

• Chongli Yu: lead

Study Sites (1)

Chinese PLA General Hosptial

Beijing, Beijing Municipality, 100853, China

Location

Related Publications (6)

• Sirufo MM, De Pietro F, Bassino EM, Ginaldi L, De Martinis M. Osteoporosis in Skin Diseases. Int J Mol Sci. 2020 Jul 3;21(13):4749. doi: 10.3390/ijms21134749.

  PMID: 32635380 BACKGROUND

• Ogdie A, Harter L, Shin D, Baker J, Takeshita J, Choi HK, Love TJ, Gelfand JM. The risk of fracture among patients with psoriatic arthritis and psoriasis: a population-based study. Ann Rheum Dis. 2017 May;76(5):882-885. doi: 10.1136/annrheumdis-2016-210441. Epub 2017 Jan 16.

  PMID: 28093419 BACKGROUND

• Sepehri NZ, Raeisi T, Razi B, Janmohammadi P, Darand M, Alizadeh S. The association between psoriasis and psoriatic arthritis with the risk of osteoporosis, osteopenia and bone fractures: A systematic review and meta-analysis. Int J Clin Pract. 2021 Nov;75(11):e14630. doi: 10.1111/ijcp.14630. Epub 2021 Jul 22.

  PMID: 34260133 BACKGROUND

• D'Epiro S, Marocco C, Salvi M, Mattozzi C, Luci C, Macaluso L, Giancristoforo S, Campoli M, Scarno M, Migliaccio S, Calvieri S, Richetta A. Psoriasis and bone mineral density: implications for long-term patients. J Dermatol. 2014 Sep;41(9):783-7. doi: 10.1111/1346-8138.12546. Epub 2014 Jul 3.

  PMID: 24990650 BACKGROUND

• Ojeda JL, Ros MA, Garcia-Porrero JA. [Role of the basement membrane in the pathogenesis of polycystic kidney: a new pathogenetic hypothesis based on an experimental model]. Minerva Urol Nefrol. 1987 Jul-Sep;39(3):275-82. No abstract available. Italian.

  PMID: 3326187 BACKGROUND

• Ding X, Wang T, Shen Y, Wang X, Zhou C, Tian S, Liu Y, Peng G, Zhou J, Xue S, Wang R, Tang Y, Meng X, Pei G, Bai Y, Liu Q, Li H, Zhang J. Prevalence of psoriasis in China: a population-based study in six cities. Eur J Dermatol. 2012 Sep-Oct;22(5):663-7. doi: 10.1684/ejd.2012.1802.

  PMID: 22910173 BACKGROUND

MeSH Terms

Conditions

Psoriasis; Bone Diseases, Metabolic

Condition Hierarchy (Ancestors)

Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PhD Candidate

Study Record Dates

• First Submitted: August 2, 2025
• First Posted: August 8, 2025
• Study Start: August 1, 2022
• Primary Completion: December 23, 2022
• Study Completion: December 23, 2022
• Last Updated: August 13, 2025

Record last verified: 2025-08

Locations

CN (1)