Intracardiac Hemodynamics and Myocardial Strain in Athletes and First Responders

NCT06075342 | Completed

• 2 other identifiers: IHMS2019YFF0301704
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to compare the differences of intracardiac hemodynamics and myocardial strain in athletes with different training levels to adapt to long-term high-level training in rest conditions. The main questions aim to answer are: 1. whether an increase in amplitude and duration of intracardiac hemodynamics and myocardial strain compared with healthy controls; 2. Whether significant correlations exist between the hemodynamic indices and training level. Participants will be asked to filling out the questionnaire, such as the age, training year (the number of years the athlete has participated in any sport), technical hierarchy (promoted by the Competitive Sports Department of the General Administration of Sport of China, weekly training time in the last 6 months, height, weight, body surface area, heart rate, systolic blood pressure, and diastolic blood pressure; and will be asked to perform an examination of transthoracic echocardiography. Researchers will compare differences of cardiac structure and function, especially the hemodynamics and myocardial strain to see if training level could affect the cardiac function through hemodynamics and myocardial strain.

Conditions

Cardiac Structure and Function; Intracardiac Hemodynamic

Outcome Measures

Primary Outcomes (2)

• intracardiac hemodynamics in mmHg/mm using vector flow mapping

  intraventricular pressure gradient from left ventricular apex to base

  through study completion, an average of 1 year

• myocardial strain in % using two-dimension tissue tracking

  left ventricular longitudinal strain

  through study completion, an average of 1 year

Secondary Outcomes (1)

• wall shear stress in pascal using vector flow mapping

  through study completion, an average of 1 year

Study Arms (4)

elite athlete

training year \> 10 years and weekly training time \> 20 hours

Behavioral: exercise

casual player

training year \< 10 years and weekly training time \< 20 hours

Behavioral: exercise

healthy control

healthy participants with irregular exercise habits

Behavioral: exercise

first responder

first responders with regular exercise training

Behavioral: exercise

Interventions

exercise BEHAVIORAL

Exercise intervention according to the training program

Also known as: exercise training

casual player; elite athlete; first responder; healthy control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

athletes with training year \> 10 and WTT \> 20, athletes with training year \< 10 and WTT \< 20, healthy controls with irregular exercise habits

You may qualify if:

• athletes and healthy control subjects without regular exercise habits;
• no specific medical history or chronic illness.

You may not qualify if:

• A previous history of arterial hypertension, diabetes mellitus, heart, kidney, hepatic, infectious, psychiatric, malignant, disorders, taking drugs that can influence ECG intervals, and electrolyte imbalance;
• poor echocardiographic image quality and abnormal segmental ventricular wall movement.

Sponsors & Collaborators

• Chengdu Sport University: lead
• Institute of Sports Medicine, General Administration of Sport of China: collaborator

Study Sites (1)

Chengdu Sport University

Chengdu, Sichuan, 610041, China

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 26, 2023
• First Posted: October 10, 2023
• Study Start: March 1, 2021
• Primary Completion: July 30, 2023
• Study Completion: July 30, 2024
• Last Updated: July 30, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will share

Locations

CN (1)