Effect of Physiological Ischemic Training on Patients With Atherosclerosis
1 other identifier
interventional
200
1 country
1
Brief Summary
To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2021
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 23, 2021
CompletedStudy Start
First participant enrolled
October 12, 2021
CompletedFirst Posted
Study publicly available on registry
October 25, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2025
CompletedOctober 25, 2021
October 1, 2021
4.2 years
September 23, 2021
October 20, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Endothelium dependent vasodilation
Percentage of the change
8 weeks
Blood lipid analysis results
Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein
8 weeks
Secondary Outcomes (2)
The inflammatory state
8 weeks
Endothelial repair function
8 weeks
Study Arms (8)
Blank control group
NO INTERVENTIONExercise group
EXPERIMENTALHyperlipidemia group
NO INTERVENTIONHyperlipidemia and medication group
NO INTERVENTIONHyperlipidemia and exercise group
EXPERIMENTALHyperlipidemia and medication and exercise group
EXPERIMENTALRoutine treatment group
NO INTERVENTIONRoutine treatment and exercise group
EXPERIMENTALInterventions
Upper limb resistance training with blood flow obstruction
Eligibility Criteria
You may qualify if:
- LDL \> 3.11mmol/l and less than 5.63mmol/l;
- No serious heart, blood vessel and other related diseases;
- There were no skeletal and muscular diseases affecting sports training;
- No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time);
- Smoking less than 1 pack / year, no history of drinking.
You may not qualify if:
- Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases;
- Pregnant women and people with disabilities;
- Other circumstances determined by the researcher not suitable for the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Nanjing First Hospital
Nanjing, Jiangsu, 210006, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Aicui Lin, PhD
Nanjing First Hospital, Nanjing Medical University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
September 23, 2021
First Posted
October 25, 2021
Study Start
October 12, 2021
Primary Completion
December 31, 2025
Study Completion
December 31, 2025
Last Updated
October 25, 2021
Record last verified: 2021-10
Data Sharing
- IPD Sharing
- Will not share