Patient Portal Flu Vaccine Reminders (RCT 6)

NCT06062264 | Completed Results

• 2 other identifiers: 17-001889-00018R01AI135029
• Study Type: interventional
• Target: 22,233
• Locations: 1 country
• Sites: 1

Brief Summary

This trial is taking place in Los Angeles, CA at 21 clinics within the UCLA Health System. The study design is a 3 arm randomized trial. Patients will be randomized into 1) receiving portal based reminder messages with a video from their PCP encouraging them to receive the influenza vaccine, 2) portal-based reminder messages with an infographic with the image of their PCP encouraging them to receive the influenza vaccine, or 3) the control group. Patients randomized to the intervention arms will receive reminders if they are due for influenza vaccine. Despite the Advisory Committee on Immunization Practices (ACIP) recommendation in 2010 that all people above 6 months of age should receive an annual flu vaccine, vaccination rates remain low: at 6m-4.9 yrs. (70%), 5-17.9 yrs. (56%), 18-64.9 yrs. (38%), and \>65 yrs. (63%). The investigators will assess the effectiveness of MyChart R/R video messages and infographic messages as compared to the standard of care control (Health system messages).

Conditions

Influenza; Respiratory Tract Infections

Keywords

Reminder Recall (R/R); Influenza Vaccine; Electronic Health Record; Vaccine; Video Messages; Trusted Messenger

Outcome Measures

Primary Outcomes (1)

• Receipt of the Annual Influenza Vaccine Among Index Patients

  Percent of patients with annual influenza vaccination (between 10/4/23 - 4/1/24) among adult patients. Outcomes will be assessed via vaccine data extraction from the electronic health record and external claims and pharmacy data. The index patients must also be an active UCLA Health MyChart user (\>= 1 login over the last 12 months from 8/1/23, excluding activity on the user's initial profile activation date). Individuals not affiliated with any primary care practice will be excluded from the primary analysis.

  6 months

Secondary Outcomes (1)

• Receipt of the Annual Influenza Vaccine Among Pediatric Index Patients

  6 months

Study Arms (3)

Portal-Based PCP Video Reminder Message

ACTIVE COMPARATOR

Participants in their arm will receive up to 3 portal-based messages with a video recorded message from their own primary care physician encouraging them to receive the influenza vaccine.

Behavioral: Portal-based Video Message

Portal-Based PCP Infographic Reminder Message

ACTIVE COMPARATOR

Participants in their arm will receive up to 3 portal-based messages with an infographic message with an image of their own primary care physician encouraging them to receive the influenza vaccine.

Behavioral: Portal-based Infographic Message

Standard Health System Portal Messages

NO INTERVENTION

Participants in this arm will only receive standard-of-care health system portal messages, and will not receive study-based messages.

Interventions

Portal-based Video Message BEHAVIORAL

Video recorded by physician encouraging patients to receive influenza vaccine. Sent via the patient portal.

Portal-Based PCP Video Reminder Message

Portal-based Infographic Message BEHAVIORAL

Infographic with information about the influenza vaccine and an image of the physician. Sent via the patient portal.

Portal-Based PCP Infographic Reminder Message

Eligibility Criteria

• Age: 6 Months+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Active Portal Users A patient within the UCLA Health System identified as a primary care patient per an internal algorithm

You may not qualify if:

• \- A patient within the UCLA Health System not identified as a primary care patient per an internal algorithm

Sponsors & Collaborators

• University of California, Los Angeles: lead
• National Institute of Allergy and Infectious Diseases (NIAID): collaborator

Study Sites (1)

University of California, Los Angeles

Los Angeles, California, 99095, United States

Location

Related Publications (1)

• Szilagyi PG, Clark EJ, Duru OK, Casillas A, Ong MK, Vangala S, Tseng CH, Albertin C, Humiston SG, Ross MK, Evans S, Kumar A, Chakarian I, Sloyan M, Fox CR, Rand CM, Lerner C. Video and Infographic Messages From Primary Care Physicians and Influenza Vaccination Rates: A Randomized Clinical Trial. JAMA Netw Open. 2025 Aug 1;8(8):e2526514. doi: 10.1001/jamanetworkopen.2025.26514.

  PMID: 40802184 DERIVED

MeSH Terms

Conditions

Influenza, Human; Respiratory Tract Infections

Condition Hierarchy (Ancestors)

Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Results Point of Contact

• Title: Principal Investigator
• Organization: UCLA

pszilagyi@mednet.ucla.edu

310-206-6328

Study Officials

• Peter Szilagyi, MD, MPH

  University of California, Los Angeles

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Executive Vice Chair, Vice Chair for Research, UCLA David Geffen School of Medicine, Department of Pediatrics, University of California, Los Angeles

Model Details: Pragmatic comparative effectiveness trial with a standard-of-care control group

Study Record Dates

• First Submitted: September 25, 2023
• First Posted: October 2, 2023
• Study Start: October 3, 2023
• Primary Completion: April 1, 2024
• Study Completion: April 1, 2024
• Last Updated: April 20, 2025
• Results First Posted: April 20, 2025

Record last verified: 2025-04

Locations

US (1)