COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion
COLLECT
The Development of Coronary Collateralization in Type 2 Diabetic Patients With Chronic Total Occlusion
1 other identifier
observational
2,000
1 country
1
Brief Summary
A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total occlusion (CTO) compared with non-diabetic patients with CTO. This retrospective cohort enrolls consecutive T2DM patients who had at least one lesion with coronary angiographic total occlusion.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2010
CompletedFirst Submitted
Initial submission to the registry
September 19, 2023
CompletedFirst Posted
Study publicly available on registry
September 26, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2026
CompletedOctober 23, 2023
August 1, 2023
16 years
September 19, 2023
October 18, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cardiac function evaluated by echocardiography
Assessed by echocardiography
12 months
Secondary Outcomes (1)
Cardiovascular events
up to 5 years
Study Arms (2)
T2DM with good CCC
T2DM was diagnosed according to the criteria of the American Diabetes Association. The diagnosis of CTO was made if at least one lesion was angiographic 100% occlusion. Coronary collateral circulation development was graded according to the Cohen-Rentrop method, grade 2 (partial filling of the epicardial segment by collateral vessels); grade 3 (complete filling of the epicardial artery by collateral vessels) were defined as good coronary collateral circulation.
T2DM with poor CCC
T2DM was diagnosed according to the criteria of the American Diabetes Association. The diagnosis of CTO was made if at least one lesion was angiographic 100% occlusion. Coronary collateral circulation development was graded according to the Cohen-Rentrop method, grade 0 (no filling of any collateral vessels) and grade 1 (filling of side branches of the artery to be perfused by collateral vessels without visualization of the epicardial segment) were defined as poor coronary collateral circulation.
Interventions
Cardiac function was evaluated by echocardiography at one year follow-up.
Eligibility Criteria
Type 2 diabetic patients with chronic total occlusion undergone coronary angiography at Ruijin Hospital, Shanghai, China are consecutively enrolled.
You may qualify if:
- Age 18-90 years
- Type 2 diabetes diagnosed by one of the following criteria:
- HbA1c \>/= 6.5% Fasting plasma glucose \>/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT \>/= 11.1 mmol/l Already receiving glucose-lowering agents.
- At least one lesion with angiographic total occlusion
You may not qualify if:
- eGFR\<15mL/(min·1.73m2)
- chronic heart failure with NYHA grade ≥3
- had a history of coronary artery bypass grafting
- had received a percutaneous coronary intervention within the prior 3 months
- Malignant tumor or immune system disorders
- Pulmonary heart disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ruijin Hospitallead
Study Sites (1)
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200025, China
Related Publications (2)
Mao LS, Wang YX, Qi Y, Yue ZR, Ding FH, Wang XQ, Lu L, Shen WF, Shen Y. Elevated Uric Acid/Albumin Ratio Predicts Poor Coronary Collateral Circulation in Type 2 Diabetic Patients With Stable Coronary Artery Disease. J Diabetes Res. 2025 Dec 19;2025:9721061. doi: 10.1155/jdr/9721061. eCollection 2025.
PMID: 41497488DERIVEDMao LS, Geng L, Wang YX, Qi Y, Wang MH, Ding FH, Dai Y, Lu L, Zhang Q, Shen WF, Shen Y. Clinical risk score to predict poor coronary collateralization in type 2 diabetic patients with chronic total occlusion. BMC Cardiovasc Disord. 2025 Apr 2;25(1):250. doi: 10.1186/s12872-025-04687-8.
PMID: 40175898DERIVED
Biospecimen
plasma and PBMCs
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 19, 2023
First Posted
September 26, 2023
Study Start
January 1, 2010
Primary Completion
December 31, 2025
Study Completion
March 1, 2026
Last Updated
October 23, 2023
Record last verified: 2023-08
Data Sharing
- IPD Sharing
- Will not share