Multicenter Normal Reference Study of Tissue Motion Tracking of Mitral Annular Displacement(TMAD)
TMAD
The Multi-center Normal Reference Study of Tissue Motion Tracking of Mitral Annular Displacement(TMAD) in Chinese Han Adults Study
1 other identifier
observational
2,400
1 country
76
Brief Summary
To establish the range of TMADmid、TMADmidpt% by using tissue motion tracking of mitral annular displacement (TMAD), and to explore the influencing factors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2020
76 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 9, 2020
CompletedFirst Posted
Study publicly available on registry
May 22, 2020
CompletedStudy Start
First participant enrolled
June 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2021
CompletedMay 22, 2020
May 1, 2020
1.1 years
May 9, 2020
May 19, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
left ventricular systolic function was measured by tissue motion tracking of mitral annular displacement（TMAD）
To establish the range of TMADmid by using TMAD
1 day
left ventricular systolic function was measured by tissue motion tracking of mitral annular displacement（TMAD）
To establish the range of TMADmidpt% by using TMAD
1 day
Secondary Outcomes (1)
left ventricular systolic function was measured by the two-plane Simpson method
1 day
Other Outcomes (1)
Serum biochemical index
1 day
Study Arms (6)
18-29 year-old group
Based on the inclusion crtiteria, 200 healthy Han people at aged 18-29 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained.
30-39 year-old group
Based on the inclusion crtiteria, 200 healthy Han people at aged 30-39 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained.
40-49 year-old group
Based on the inclusion crtiteria, 200 healthy Han people at aged 40-49 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained.
50-59 year-old group
Based on the inclusion crtiteria, 200 healthy Han people at aged 50-59 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained.
60-69 year-old group
Based on the inclusion crtiteria, 200 healthy Han people at aged 60-69 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained.
70-79 year-old group
Based on the inclusion crtiteria, 200 healthy Han people at aged 70-79 and both sexes will be recruited in the analysis. Normal reference values of tissue motion tracking of mitral annular displacement will be obtained.
Interventions
left ventricular systolic function of all participants were measured by tissue motion tracking of mitral annular displacement using PHILIPS
Eligibility Criteria
2400 healthy adults with normal physical examination items will be selected from the physical examination center. According to sex and age stratification, totally 2400 cases will contain 1200 males and 1200 females. From 18 to 79 years old, they will be divided into 6 groups: 18-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years and 70-79 years (n=400 per group).
You may qualify if:
- Han nationality
- Ages 18-79.
- Normal body mass index (18-25kg / m2).
- Normal blood pressure (139-90 / 89-60mmHg).
- No history of cardiovascular and respiratory diseases.
- No abnormality was found in physical examination of cardiovascular and respiratory system.
- Blood glucose, lipid profile and electrocardiogram were normal.
- Echocardiography showed no structural heart disease and normal heart function.
- No history of medications affecting cardiovascular system.
You may not qualify if:
- Clinically significant or moderate heart valve regurgitation.
- Respiratory diseases: acute or chronic respiratory diseases.
- Endocrine diseases: thyroid disease, diabetes, hyperaldosteronism, pheochromocytoma, and abnormal adrenal function.
- Anemia.
- Pregnant or lactating women.
- Abnormal liver function (glutamyl aminotransferase exceeds 2.0 times the upper limit of normal value), abnormal renal function (creatinine exceeds the normal value), increased blood lipids (triglycerides, total cholesterol, low density and high density lipoprotein, any of which is higher than Normal value).
- Connective tissue disease.
- Tumor.
- Aortic and peripheral vascular diseases: aortic dilatation, aortic dissection, aortic constriction, multiple arteritis, and atherosclerosis.
- Drink more than 50ml of white wine daily; more than 100ml of red wine; more than 300ml of beer.
- Professional athletes.
- The poor quality of the ultrasound image cannot satisfy the parameter measurement and analysis.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Weidong Renlead
Study Sites (76)
Anhui Provincial Hospital
Hefei, Anhui, China
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China
Gansu Baiyin Second People's Hospital
Baiyin, Gansu, China
The First People's Hospital of Foshan City
Foshan, Guangdong, China
The People's Hospital of Gaozhou
Gaozhou, Guangdong, China
the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
Qingyuan People's Hospital
Qingyuan, Guangdong, China
Affiliated Hospital of YouJiang Medical University for Nationalities
Baise City, Guangxi, China
People'S Hospital of Baise
Baise City, Guangxi, China
The People'S Hospital of Chong Zuo
Chongzuo, Guangxi, China
Guigang City People'S Hospital
Guigang, Guangxi, China
Laibin People's Hospital
Laibin, Guangxi, China
Guangxi International Zhuang Medical Hospital
Nanning, Guangxi, China
Guangxi Minzu Hospital
Nanning, Guangxi, China
The first peopel's hospital of yulin
Yulin, Guangxi, China
The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China
Nanyang Second People's Hospital
Nanyang, He'nan, China
Fengning Manchu Autonomous County Hospital
Chengde, Hebei, China
Handan First Hospital
Handan, Hebei, China
shijiazhuang No.1 Hospital
Shijiazhuang, Hebei, China
The Fourth Hospital of Heibei Medical University Hebei Cancer Hospital
Shijiazhuang, Hebei, China
Tangshan fengnan district hospital
Tangshan, Hebei, China
Xingtai Third Hospital
Xingtai, Hebei, China
Mudanjiang Cardiovascular Hospital
Mudanjiang, Heilongjiang, China
The Third Affiliated Hospital of Qiqihar Medical Hospital
Qiqihar, Heilongjiang, China
People'S Hospital of Hunan Province
Changsha, Hunan, China
The First People's Hospital of Huaihua
Huaihua, Hunan, China
The First Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, China
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China
Jiujiang University Affiliated Hospital
Jiujiang, Jiangxi, China
Baicheng Central Hospital
Baicheng, Jilin, China
Jilin Central General Hospital
Jilin, Jilin, China
Benxi Central Hospital
Benxi, Liaoning, China
Chaoyang Central Hospital
Chaoyang, Liaoning, China
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, 116011, China
Dalian Municipal Central Hospital
Dalian, Liaoning, 116033, China
The Second Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China
DanDong central hospital
Dandong, Liaoning, China
Fuchun Central Hospital
Fushun, Liaoning, China
General Hospital of Fushun Mining Bureau
Fushun, Liaoning, China
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, Liaoning, China
Shengjing Hospital of China Medical University
Shenyang, Liaoning, 110004, China
Central Hospital Affiliated To ShenYang Medical College
Shenyang, Liaoning, China
The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
Shenyang, Liaoning, China
The First Hospital of China Medical University
Shenyang, Liaoning, China
The People'S Hospital of Liaoning Province
Shenyang, Liaoning, China
the Second Affiliated Hospital Of Shenyang Medical College
Shenyang, Liaoning, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
Qinghai Provincial People's Hospital
Xining, Qinghai, China
The Second Hospital of Shandong University
Jinan, Shandong, China
Liaocheng People'S Hospital
Liaocheng, Shandong, China
Yantai Affiliated Hospital of Binzhou Medical University
Yantai, Shandong, China
Zibo City Linzi District People's Hospital
Zibo, Shandong, China
Shanghai Pudong New District Zhoupu Hospital
Shanghai, Shanghai Municipality, China
Baoji Central Hospital
Baoji, Shanxi, China
Hanzhong Central Hospital
Hanzhong, Shanxi, China
Xianyang Central Hospital
Xianyang, Shanxi, China
Shaanxi Provincial People'S Hospital
Xi’an, Shanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi’an, Shanxi, China
Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Chengdu, Sichuan, China
Chengdu First People's Hospital
Chengdu, Sichuan, China
Chengdu Second People'S Hospital
Chengdu, Sichuan, China
Chengdu Third People's Hospital
Chengdu, Sichuan, China
The Peoplep'S Hospital of Wenjiang District,Chengdu
Chengdu, Sichuan, China
West China-Guang'An Hospital,Sichuan University
Guang’an, Sichuan, China
The People's Hospital Of Leshan
Leshan, Sichuan, China
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan, China
Affiliated Hospital of North Sichuan Medical College
Nanchong, Sichuan, China
Nanchong Central Hospital
Nanchong, Sichuan, China
Panzhihua Central Hospital
Panzhihua, Sichuan, China
Suining Central Hospital
Suining, Sichuan, China
First Affiliated Hospital,School of Medical,Shihezi University
Shihezi, Xinjiang, China
Urumqi Friendship Hospital
Ürümqi, Xinjiang, China
Dali Bai Autonomous Prefecture People'S Hospital
Dali, Yunnan, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Weidong Ren
Shengjing Hospital of China Medical Univeristy
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Chief of Ultrasound
Study Record Dates
First Submitted
May 9, 2020
First Posted
May 22, 2020
Study Start
June 1, 2020
Primary Completion
June 30, 2021
Study Completion
September 30, 2021
Last Updated
May 22, 2020
Record last verified: 2020-05