Use of Personalized Recommendations, Through Genetic and Lifestyle Data, to Improve Healthcare Staff Wellbeing

NCT06042452 | Not Yet Recruiting

• 1 other identifier: FG-NHS-Wellbeing
• Study Type: interventional
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

With the NHS under increasing pressure and strain, the health and wellbeing of staff is an important area to prioritize, to help reduce staff stress levels and increase retention of staff. This study will look to explore how efficacious personalised insights and recommendations are, based on genetic and lifestyle information, at improving the health and wellbeing of NHS employees. It will also explore how sustainable these recommendations are for long-term change. Recruitment of NHS staff as participants will take place across multiple NHS trusts including Bradford Teaching Hospital NHS Trust and Sandwell and West Birmingham NHS Trust. Following consent to partake in the trial, participants will be asked to complete a pre-trial questionnaire which will explore health and wellbeing interests and motivations, perceptions of genetic testing, and a baseline measure of mental and physical wellbeing using a standardised and validated questionnaire (5-item World Health Organisation Well-being Index (WHO-5)). This, and all further questionnaires, will be completed online. Participants will undertake a DNA test provided by FitnessGenes, free of charge. This test will require participants to provide a saliva sample via a spit test. This sample will then be analysed at an ISO-accredited laboratory and results provided back to the participant within 2-3 weeks. While awaiting the results, participants will have access to lifestyle traits calculated using questionnaire data collected when creating a FitnessGenes account. Once their genetic data is added to a participant's FitnessGenes accounts, they will be asked to spend two weeks exploring this information. A questionnaire will then be completed to reassess participant's wellbeing measures and any changes in their perceptions of DNA testing. At this stage, some semi-structured interviews may be conducted, to those who consent to this, to gain further insight. A 3-month follow up will be completed to assess whether the platform has had any long-lasting impacts on participants' health and wellbeing.

Conditions

Well-Being, Psychological

Outcome Measures

Primary Outcomes (1)

• Change in physical and psychological well-being

  5-Item World Health Organisation Well-being Index (WHO-5). This uses a Likert Scale from 0 ('At no time') to 5 ('All of the time'). A raw score of 0 (lowest well-being) to 25 (highest well-being) is possible on the WHO-5.

  Measurements taken at baseline, 3 weeks following receiving personalized recommendations, and at a 3 month follow-up

Secondary Outcomes (2)

• Perceptions of DNA testing

  Measurements taken at baseline, 3 weeks following receiving personalized recommendations, and at 3 month follow-up

• How sustainable are the personalized recommendations

  Measurements taken at 3 month follow-up

Study Arms (1)

Genetic

EXPERIMENTAL

Participants will have their DNA tested and this data alongside lifestyle data will personalize the information they receive

Genetic: Genetic

Interventions

Genetic GENETIC

A saliva sample test will be undertaken by all participants in order to analyze their DNA for personalizing their recommendations. The Global Screening Array (GSA) will be used.

Genetic

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Health care staff within the NHS (including both clinical and administrative)
• Able to proficiently read English (reports are only produced in English)

You may not qualify if:

• Unable to proficiently read English

Sponsors & Collaborators

• FitnessGenes Ltd.: lead

Related Publications (4)

• Ricciardi W, Boccia S. New challenges of public health: bringing the future of personalised healthcare into focus. Eur J Public Health. 2017 Oct 1;27(suppl_4):36-39. doi: 10.1093/eurpub/ckx164.

  PMID: 29028243 BACKGROUND

• Sauerteig SO, Wijesuriya J, Tuck M, Barham-Brown H. Doctors' health and wellbeing: at the heart of the NHS's mission or still a secondary consideration? Int Rev Psychiatry. 2019 Nov-Dec;31(7-8):548-554. doi: 10.1080/09540261.2019.1586165. Epub 2019 May 14.

  PMID: 31084440 BACKGROUND

• Topp CW, Ostergaard SD, Sondergaard S, Bech P. The WHO-5 Well-Being Index: a systematic review of the literature. Psychother Psychosom. 2015;84(3):167-76. doi: 10.1159/000376585. Epub 2015 Mar 28.

  PMID: 25831962 BACKGROUND

• Ghasemi A, Zahediasl S. Normality tests for statistical analysis: a guide for non-statisticians. Int J Endocrinol Metab. 2012 Spring;10(2):486-9. doi: 10.5812/ijem.3505. Epub 2012 Apr 20.

  PMID: 23843808 BACKGROUND

Related Links

• Advancing personalized care being a key focus in the NHS Long Term Plan
• Select Committee on the Long-term Sustainability of the NHS: Chapter 6: Public health, prevention and patient responsibility

MeSH Terms

Conditions

Psychological Well-Being

Condition Hierarchy (Ancestors)

Personal Satisfaction; Behavior

Study Officials

• Stuart Grice, DPhil

  FitnessGenes Ltd.

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Geraldine M Campbell, MSc

CONTACT

01869255770; geraldine.campbell@fitnessgenes.com

Samantha Decombel, PhD

CONTACT

01869255770; sam@fitnessgenes.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2023
• First Posted: September 18, 2023
• Study Start: January 1, 2025
• Primary Completion: February 1, 2025
• Study Completion: March 1, 2025
• Last Updated: February 28, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share