Prognosis in Patients With Guillain-Barre Syndrome

NCT06032741 | Unknown

• 1 other identifier: GBS
• Study Type: observational
• Target: 450
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to explore significant indicators to predict the early prognosis and late prognosis in patients with Guillain-Barre syndrome.

Conditions

Guillain-Barre Syndrome

Keywords

Guillain-Barre Syndrome

Outcome Measures

Primary Outcomes (1)

• the severity of Guillain-barre syndrome

  The Guillain-Barre syndrome disability score is a wide scale for the severity of Guillain-Barre syndrome (0, optimal health; 1, minor symptoms, able to run; 2, able to walk unaided 10 m, unable to run; 3, able to walk 10 m across an open space with help; 4 bedridden or wheelchair users; 5, require assisted ventilation; 6, dead)(deceased).The higher the score, the worse the prognosis.

  baseline, at 1 week, at 26 weeks

Study Arms (2)

mechanical ventilation group

Patients with Guillain-Barré Syndrome require mechanical ventilation during hospitalization

no mechanical ventilation group

Patients with Guillain-Barré Syndrome do not require mechanical ventilation during hospitalization

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This is a multicenter study(approximately three) with over 450 subjects.Clinical data were collected by consulting the patient's electronic history. The data included demographic information, blood biochemical markers, clinical characteristics and electromyography. All participants provided their written informed consent to participate in this study.

You may qualify if:

• patients fulfilled clinical, biological, and electrophysiology criteria for Guillain-barre syndrome.

You may not qualify if:

• nonidiopathic Guillain-barre syndrome and Miller Fisher syndrome

Sponsors & Collaborators

• First Affiliated Hospital of Wenzhou Medical University: lead

Study Sites (1)

First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, 325000, China

RECRUITING

MeSH Terms

Conditions

Guillain-Barre Syndrome

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Binbin Deng

CONTACT

dbinbin@aliyun.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 26, 2022
• First Posted: September 13, 2023
• Study Start: January 2, 2013
• Primary Completion: December 1, 2022
• Study Completion: January 31, 2025
• Last Updated: September 13, 2023

Record last verified: 2022-12

Locations

CN (1)