Effects of Proprioceptive Neuromuscular Training on Sensory and Motor Function in Guillain Barre Syndrome

NCT05491096 | Completed

• 1 other identifier: REC/22/0219 Salma
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to determine the effects of Proprioceptive Neuromuscular Training on Sensory versus Motor Function in patients presenting with Guillain Barre Syndrome.

Conditions

Guillain-Barre Syndrome

Keywords

Guillain Barre Syndrome; Proprioceptive Neuromuscular Training; Balance; Motor Function; Sensory Function

Outcome Measures

Primary Outcomes (3)

• Berg Balance Scale

  The Berg balance scale is used to objectively determine a patient's ability (or inability) to safely balance during a series of predetermined tasks. It is a 14 item list with each item consisting of a five-point ordinal scale ranging from 0 to 4, with 0 indicating the lowest level of function and 4 the highest level of function and takes approximately 20 minutes to completed.

  12th Week

• Time up and go test

  It is used to determine fall risk and measure the progress of balance, sit to stand and walking.It is Simple screening test that is a sensitive and specific measure of probability for falls among older adults.

  12th Week

• One leg stance test

  The Single leg Stance Test is used to assess static postural and balance control. Balance assessments are a valuable clinical tool for monitoring neurological and musculoskeletal status as well as for managing fall risk.

  12th Week

Study Arms (2)

Proprioceptive Neuromuscular Training

EXPERIMENTAL

It consists of 13 patients who will receive conventional exercises and proprioceptive training with 2 sessions per week for 8 weeks.

Other: Proprioceptive Neuromuscular Training

Conventional Physical Therapy

PLACEBO COMPARATOR

It consists of 13 patients who will receive conventional exercises i.e; strengthening exercises, 2 sessions per week for 8 weeks

Other: Conventional Physical Therapy

Interventions

Proprioceptive Neuromuscular Training OTHER

Proprioceptive exercises will be divided into three components. The first component will be comprised of standing on Foam with eyes open and eyes closed and passing any object from one subject to the other for 10 minutes. The second component consists of activity that will be performed in groups of two. Throwing and catching a ball will be performed while standing on foam for additional10 minutes. The third component, throwing and catching a ball, will be performed on trampoline to further challenge the balance system. After each set of 10-minute exercise, the subjects will be given two-minute resting periods. In the end, 10 minutes will be given for cooling down in which deep breathing exercises and static back extensor stretching exercises will be performed to avoid fatigue and to bring the heart rate back to the normal resting level.

Proprioceptive Neuromuscular Training

Conventional Physical Therapy OTHER

Conventional treatment protocolconsists of a structured exercise protocol Each training session consisted of three parts, the first part included the main movements (warming up 10 minutes plus 5 minutes stretching exercises), the second part consisted of specific movements (exercises with theraband and physioball, 20 minutes), and the third part composed of cool down exercises (10 minutes).(22)Experimental treatment protocolwill be proprioceptive training program. PTP will be based on earlier studies, and will be carried out for eight weeks, with two 60-minute sessions per week. It will start with 10 minutes of Warm-up activities when the subjects will be advised to do light manual stretches and to step up and down on foam to get their body warmed up to have improve muscular flexibility. This will be followed by 30 minutes of proprioceptive exercises targeting lower extremities.

Conventional Physical Therapy

Eligibility Criteria

• Age: 10 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Diagnosed with Guillain Barre Syndrome already taking treatments
• Inflammatory Demyelinating Guillain Barre Syndrome patients
• Acute motor sensory axonal neuropathy
• Guillain Barre Syndrome patients in the subacute phase
• Guillain Barre Syndrome patients with impaired proprioception
• Patients with Glasgow Coma Scale above 12

You may not qualify if:

• Other Guillain Barre Syndrome types
• Spinal cord injury
• Traumatic neuritis
• Not Fulfilling Above Criteria Of Age

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

psrd (pakistan Society for the rehabilitation of the disabled)

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Guillain-Barre Syndrome

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Sara Aabroo

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 14, 2022
• First Posted: August 8, 2022
• Study Start: June 5, 2022
• Primary Completion: February 28, 2023
• Study Completion: February 28, 2023
• Last Updated: August 1, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)