Predictive Value of Neuromuscular Ultrasound of Cranial Nerves in Guillain-Barré Syndrome

NCT06200454 | Unknown

• 1 other identifier: U/S of cranial nerves in GBS
• Study Type: observational
• Target: 102
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Sensitivity and specificity of cranial neuromuscular US to detect the prognosis of Guillain Barre Syndrome
2. 2.Correlation of US values with motor, respiratory and autonomic complications of Guillain Barre Syndrome

Conditions

Guillain-Barre Syndrome

Outcome Measures

Primary Outcomes (1)

• Predictive value of neuromuscular ultrasound of cranial nerves in Guillain-Barré syndrome

  analysis of ultrasound results and follfow up of the cases to see if neuromuscular ultrasound of cranial nerves can predict the prognosis in Guillain-Barré syndrome

  baseline

Study Arms (2)

Guillain-Barré syndrome patients

neuromuscular ultrasound of cranial nerves

Device: neuromuscular ultrasound of cranial nerves

normal participants

neuromuscular ultrasound of cranial nerves

Device: neuromuscular ultrasound of cranial nerves

Interventions

neuromuscular ultrasound of cranial nerves DEVICE

neuromuscular ultrasound of cranial nerves.

Guillain-Barré syndrome patients; normal participants

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Guillain-Barré syndrome (GBS) is a dangerous and under certain circumstances life-threatening immune-mediated polyneuropathy of acute onset, often subsequent to respiratory or diarrheal illness. Patients usually present with distal onset of slight sensory symptoms such as numbness and tingling followed by ascending weakness of arms and legs, often involving cranial nerves Typical clinical findings are symmetric, flaccid paresis, reduced or absent deep tendon reflexes, and slight sensory symptoms only. Many variants of GBS such as pharyngeal-brachial or bulbar variants exist; the Miller-Fisher syndrome (MFS) with ataxia, areflexia, and oculomotor dysfunction; or the Elsberg syndrome with accentuated involvement of the autonomic nervous system. Diagnosis of GBS is normally based on typical clinical onset, laboratory findings, and electrophysiological studies.

You may qualify if:

• Patients fulfilling the diagnostic criteria of GBS within the first 2 weeks.
• Age: 18-65
• Both sexes

You may not qualify if:

• Past history of previous similar condition or history suggestive of CIDP.
• Any proved alternative diagnosis like hypo- or hyperkalemic paralysis, porphyria, or myositis.
• Other possible causes of peripheral neuropathy, diabetes, renal, and other metabolic disorders.
• History of Autonomic or cardiopulmonary dysfunction before the onset of symptoms.
• Patients who refused to participate or sign an informed consent.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Wilder-Smith EP. Swollen nerves slimming: Sequential nerve ultrasound in acute Guillain-Barre syndrome. Clin Neurophysiol. 2016 Feb;127(2):1013-1014. doi: 10.1016/j.clinph.2015.07.010. Epub 2015 Jul 17. No abstract available.

  PMID: 26210255 BACKGROUND

• Abdelnaby R, Elsayed M, Mohamed KA, Dardeer KT, Sonbol YT, ELgenidy A, Barakat MH, NasrEldin YK, Maier A. Sonographic Reference Values of Vagus Nerve: A Systematic Review and Meta-analysis. J Clin Neurophysiol. 2022 Jan 1;39(1):59-71. doi: 10.1097/WNP.0000000000000856.

  PMID: 34144573 BACKGROUND

• Guven SC, Bilgin E, Ozcakar L. Ultrasound imaging of the accessory nerve injury in a patient with thrombotic thrombocytopenic purpura and polyneuropathy. Am J Phys Med Rehabil. 2014 Oct;93(10):928. doi: 10.1097/PHM.0000000000000130. No abstract available.

  PMID: 24919085 BACKGROUND

• Curcean AD, Rusu GM, Dudea SM. Ultrasound appearance of peripheral nerves in the neck: vagus, hypoglossal and greater auricular. Med Pharm Rep. 2020 Jan;93(1):39-46. doi: 10.15386/mpr-1273. Epub 2020 Jan 31.

  PMID: 32133445 BACKGROUND

MeSH Terms

Conditions

Guillain-Barre Syndrome

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

mohamed abdallah, master

CONTACT

01094700462; moha.abdallah4444@yahoo.com

doaa mokhtar

CONTACT

01005308849; doaamokhtarmahmoud@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: December 28, 2023
• First Posted: January 11, 2024
• Study Start: January 8, 2024
• Primary Completion: January 8, 2025
• Study Completion: June 8, 2025
• Last Updated: January 11, 2024

Record last verified: 2023-12