Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment

NCT06029920 | Completed

• 1 other identifier: IKFR.2023.08.01
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to investigate the impact of overground walking as a part of a rehabilitation program on the increase in Brain-derived neurotrophic factor (BDNF) levels, decrease in IL-6 levels, decrease in hs-CRP levels, improvement in cognitive function, and enhancement of quality of life (QOL) in older people with mild cognitive impairment. These findings are anticipated to contribute to the efforts to elevate BDNF levels, cognitive function, and QOL while reducing IL-6 and hsCRP levels in the elderly with mild cognitive impairment.

Conditions

Cognitive Impairment; Aging

Keywords

Exercise; Rehabilitation

Outcome Measures

Primary Outcomes (5)

• BDNF

  Brain-derived neurotrophic factor level

  8 weeks

• IL6

  Interleukin-6 level

  8 weeks

• hsCRP

  hs-CRP level

  8 weeks

• MoCAINA

  MONTREAL COGNITIVE ASSESSMENT INDONESIA

  8 weeks

• ADQOL

  Alzheimer disease Quality of Life

  8 weeks

Study Arms (1)

Subjects

EXPERIMENTAL

Other: Overground Walking

Interventions

Overground Walking OTHER

Walk on a flat surface for a distance of 15 meters, with a duration of 20 minutes, increasing by 5 minutes each week until the target heart rate is achieved during the exercise, for 8 weeks.

Subjects

Eligibility Criteria

• Age: 60 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Mild cognitive impairment (MoCA INA Score 19-25 out of 30
• Barthel Index Score 20
• Geriatric Depression Scale Score ≤ 5
• Timed Up and Go Test \< 15 seconds)
• Capable of comprehending verbal and written instructions
• Capable of walking unassisted

You may not qualify if:

• The presence of hearing impairment that could hinder the subject from receiving verbal instructions,
• The presence of uncorrected visual impairment
• Having musculoskeletal disorders
• Receiving other rehabilitation programs,
• Presence of diseases causing cognitive impairment
• Severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or could pose difficulties in carrying out the exercise program,
• Severe cardiovascular diseases as diagnosed by a Cardiologist

Sponsors & Collaborators

• Universitas Padjadjaran: lead

Study Sites (1)

Nursing Home

Bandung, West Java, Indonesia

Location

Related Publications (10)

• Amieva H, Letenneur L, Dartigues JF, Rouch-Leroyer I, Sourgen C, D'Alchee-Biree F, Dib M, Barberger-Gateau P, Orgogozo JM, Fabrigoule C. Annual rate and predictors of conversion to dementia in subjects presenting mild cognitive impairment criteria defined according to a population-based study. Dement Geriatr Cogn Disord. 2004;18(1):87-93. doi: 10.1159/000077815. Epub 2004 Apr 14.

  PMID: 15087583 BACKGROUND

• Barrios H, Narciso S, Guerreiro M, Maroco J, Logsdon R, de Mendonca A. Quality of life in patients with mild cognitive impairment. Aging Ment Health. 2013;17(3):287-92. doi: 10.1080/13607863.2012.747083. Epub 2012 Dec 7.

  PMID: 23215827 BACKGROUND

• Bavelier D, Neville HJ. Cross-modal plasticity: where and how? Nat Rev Neurosci. 2002 Jun;3(6):443-52. doi: 10.1038/nrn848.

  PMID: 12042879 BACKGROUND

• Burkhalter TM, Hillman CH. A narrative review of physical activity, nutrition, and obesity to cognition and scholastic performance across the human lifespan. Adv Nutr. 2011 Mar;2(2):201S-6S. doi: 10.3945/an.111.000331. Epub 2011 Mar 10.

  PMID: 22332052 BACKGROUND

• Chieffi S, Messina G, Villano I, Messina A, Valenzano A, Moscatelli F, Salerno M, Sullo A, Avola R, Monda V, Cibelli G, Monda M. Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies. Front Neurol. 2017 May 22;8:188. doi: 10.3389/fneur.2017.00188. eCollection 2017.

  PMID: 28588546 BACKGROUND

• Dik M, Deeg DJ, Visser M, Jonker C. Early life physical activity and cognition at old age. J Clin Exp Neuropsychol. 2003 Aug;25(5):643-53. doi: 10.1076/jcen.25.5.643.14583.

  PMID: 12815502 BACKGROUND

• Espino DV, Lichtenstein MJ, Palmer RF, Hazuda HP. Ethnic differences in mini-mental state examination (MMSE) scores: where you live makes a difference. J Am Geriatr Soc. 2001 May;49(5):538-48. doi: 10.1046/j.1532-5415.2001.49111.x.

  PMID: 11380745 BACKGROUND

• Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med. 2013 Nov;29(4):737-52. doi: 10.1016/j.cger.2013.07.002.

  PMID: 24094294 BACKGROUND

• Shams A, Nobari H, Afonso J, Abbasi H, Mainer-Pardos E, Perez-Gomez J, Bayati M, Bahrami A, Carneiro L. Effect of Aerobic-Based Exercise on Psychological Well-Being and Quality of Life Among Older People: A Middle East Study. Front Public Health. 2021 Dec 6;9:764044. doi: 10.3389/fpubh.2021.764044. eCollection 2021.

  PMID: 34938705 BACKGROUND

• Xue J, Li J, Liang J, Chen S. The Prevalence of Mild Cognitive Impairment in China: A Systematic Review. Aging Dis. 2018 Aug 1;9(4):706-715. doi: 10.14336/AD.2017.0928. eCollection 2018 Aug.

  PMID: 30090658 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction; Motor Activity

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 1, 2023
• First Posted: September 8, 2023
• Study Start: September 5, 2023
• Primary Completion: October 31, 2023
• Study Completion: October 31, 2023
• Last Updated: November 7, 2023

Record last verified: 2023-11

Locations

ID (1)