The Effect of Upper Limb Low-intensity Motor Control Training Program on Cognitive Function in Healthy Older Adults

NCT06962722 | Recruiting

• 1 other identifier: FMHS 331-0723
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This healthy volunteer intervention study is designed to evaluate the effectiveness of upper limb motor control training (uMCT) on physical and cognitive functions in older adults. The primary objectives of the study are twofold: Assess the Impact on Physical and Neuromuscular Function: The study seeks to determine whether uMCT positively influences physical performance, including motor coordination and neuromuscular function, in older adults. Assessment the Impact on Cognitive Function: The study aims to investigate whether uMCT enhances cognitive abilities in older adults. In addition to these main goals, the study will also assess the feasibility and safety of implementing uMCT in an older adult population. The main questions it aims to answer are: Does uMCON training have a positive effect on physical function and neuromuscular function in older adults? Does uMCON training have a positive effect on cognitive function in older adults? The researchers designed this study to show whether uMCON training works on physical function (balance, gait, and so on) and cognition in older adults. Participants will come to Derby Royal Hospital Medical School to attend uMCON training three days a week for 1 month. They will attend pre-training, post-training, and follow-up (after 1 month) control assessment sessions.

Conditions

Cognitive Impairment

Keywords

neuromuscular training; older adults; cognitive impairment; exercise

Outcome Measures

Primary Outcomes (1)

• Outcome Measure Title: Rate of participants whose cognition improved with upper limb motor control training.

  Number of Participants: 20 Control group: No Rate of Female/Male: 50%/ 50% Time frame: 1 month upper limb neuromuscular training Assessment time: Pre-training, Post-training, Follow-up(after 4 weeks) Cognition questionnaire is used (MOCA).

  Baseline, 4 week, and 8 week

Secondary Outcomes (2)

• Clinically relevant functional outcomes (motor control, strength, dexterity, overall physical function)

  Baseline, 4 week, and 8 week

• Plasma pro/anti-inflammatory cytokine levels

  Baseline, 4 week, and 8 week

Study Arms (1)

Intervention Group

EXPERIMENTAL

uMCON training group

Other: Upper limb motor control training (uMCON)

Interventions

Upper limb motor control training (uMCON) OTHER

The exercise program protocol was determined using elbow flexion (Biceps brachii) and elbow extension (Triceps) on a special platform developed for the arm. In this computer-based exercise, participants are asked to follow a small ball on the screen in different lines at certain percentages of maximum muscle strength (10%, 25%, 50%, and so on). Neuromuscular training will be worked on with this exercise.

Intervention Group

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Willing and able to give informed consent for participation in the study
• Aged between 65-85 years

You may not qualify if:

• Diagnosis of cognitive impairment
• Current or recent (\<5y) malignancy
• History of or current psychiatric illness
• History of or current neurological condition (e.g., epilepsy, Parkinsons disease, cerebrovascular disease)
• Severe respiratory disease (e.g., uncontrolled asthma, COPD, pulmonary hypertension)
• Active cardiovascular disease: Uncontrolled hypertension (BP\>160/100mmHg); Recent (\<12mo) cardiac event; Heart failure (Class III/IV); Significant arrhythmia; Unstable angina
• Metabolic disease: Untreated hyper/hypo-parathyroidism; Cushing's disease; Type 1 or 2 diabetes
• Significant musculoskeletal disorders (based on clinical opinion)
• Family history of early (\<55y) death from cardiovascular disease

Sponsors & Collaborators

• University of Nottingham: lead

Study Sites (1)

The University of Nottingham Medical School

Derby, Derbyshire, DE22 3DT, United Kingdom

RECRUITING

MeSH Terms

Conditions

Cognitive Dysfunction; Motor Activity

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Behavior

Study Officials

• Hatice Sirin Ekici, PhD

  The University of Nottingham

  STUDY DIRECTOR

• Mehmet C Yildirim, PhD

  The University of Nottingham

  STUDY DIRECTOR

Central Study Contacts

Bethan E Phillips, Professor

CONTACT

01332 724676; beth.phillips@nottingham.ac.uk

Jemima Collins, Assist Prof

CONTACT

jemima.collins.old@nottingham.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 27, 2024
• First Posted: May 8, 2025
• Study Start: September 1, 2023
• Primary Completion (Estimated): May 31, 2026
• Study Completion (Estimated): May 31, 2026
• Last Updated: May 8, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)