NCT06024486

Brief Summary

The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA)

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Nov 2023

Shorter than P25 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 14, 2023

Completed
23 days until next milestone

First Posted

Study publicly available on registry

September 6, 2023

Completed
2 months until next milestone

Study Start

First participant enrolled

November 1, 2023

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2024

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2024

Completed
Last Updated

October 6, 2023

Status Verified

October 1, 2023

Enrollment Period

6 months

First QC Date

August 14, 2023

Last Update Submit

October 5, 2023

Conditions

Juvenile Idiopathic Arthritis

Outcome Measures

Primary Outcomes (3)

  • The fibrinogen to albumin ratio

    measurement of serum fibrinogen and albumin

    3 months

  • The CRP to albumin ratio

    measurement of serum CRP and albumin

    3 MONTHS

  • Correlation of fibrinogen to albumin and CRP to albumin ratios on one side with disease activity on the other side

    correlation of these ratios with JADAS27

    3 MONTHS

Study Arms (2)

JIA cases

juvenile idiopathic arthritis cases

Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)

CONTROL

age and sex matched healthy controls

Diagnostic Test: fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)

Interventions

fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)DIAGNOSTIC_TEST

measurement of serum albumin, fibrinogen and CRP

CONTROLJIA cases

Eligibility Criteria

AgeUp to 16 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)
Sampling MethodProbability Sample
Study Population

All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects.

You may qualify if:

  • All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects

You may not qualify if:

  • Other systemic inflammatory or autoimmune disorders.
  • History of corticosteroid medication in the last 6 months.
  • Liver diseases.
  • Malignancy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Arthritis, Juvenile

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
principal investigator

Study Record Dates

First Submitted

August 14, 2023

First Posted

September 6, 2023

Study Start

November 1, 2023

Primary Completion

May 1, 2024

Study Completion

July 1, 2024

Last Updated

October 6, 2023

Record last verified: 2023-10