Assessment of Composite Inflammatory Ratios in Juvenile Idiopathic Arthritis and Their Association With Disease Activity

NCT07083466 | Not Yet Recruiting

• 1 other identifier: Soh-Med-25-6-6MS
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Juvenile Idiopathic Arthritis (JIA) is a prevalent pediatric rheumatic disorder characterized by persistent inflammation of one or more joints in children and adolescents. This chronic condition is a major contributor to both short- and long-term morbidity and functional disability We aim in this study to investigate the role of CAR, PLR, NLR ,systemic inflammatory index (SII ) and NAR ( SII and NAR have never been evaluated before in JIA patients ) as potential markers of disease activity in patients with non-systemic JIA (nsJIA) .

Conditions

Juvenile Idiopathic Arthritis

Outcome Measures

Primary Outcomes (4)

• possibility to use crp to albumin level as novel biomarker to predict disease activity in juvenile 0idiopathic arthritis

  6 months

• possibility to detect systemic inflammatory index and its relation to disease activity and risk of flare in juvenile idiopathic arthritis

  6 months

• assessment of activity of disease according to JDAS SCORE

  6 months

• assessment of neutrophils to albumin ratio and its relation to JDAS score activity score

  6 months

Study Arms (2)

case

cases under 16y established diagnosis juvenile idiopathic arthritis

Diagnostic Test: complete blood count; Diagnostic Test: serum albumin

control

below age 16 y not diagnosed with any autoimmune or systemic disease

Diagnostic Test: complete blood count; Diagnostic Test: serum albumin

Interventions

complete blood count DIAGNOSTIC_TEST

blood test

case; control

serum albumin DIAGNOSTIC_TEST

blood test

case; control

Eligibility Criteria

• Age: Up to 16 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

The study will include 60 patients classified as JIA according International League of Associations for Rheumatology ILAR criteria on treatment who will recruited from Rheumatology and Rehabilitation department at Sohag University hospital in addition to 30 healthy individual volunteers without history of any systemic active disease recruited from the community as age and sex matched controls

You may qualify if:

• \. Patients with disease duration more than 6 months. 3. Age below 16 years old. 4. Patient cooperative and can answer questions. 5. Patients who are able and willing to give written informed consent or their parents/guardians

You may not qualify if:

• \. Systemic JIA. 2. Patients with other autoimmune or autoinflammatory diseases, immunodeficiencies, hematologic conditions, malignances and infectious disease at enrollment time or in the previous 2 weeks.
• Patients who are not able and willing to give written informed consent

Sponsors & Collaborators

• Sohag University: lead

Related Publications (4)

• Huang JL. New advances in juvenile idiopathic arthritis. Chang Gung Med J. 2012 Jan-Feb;35(1):1-14. doi: 10.4103/2319-4170.106171.

  PMID: 22483423 BACKGROUND

• Prakken B, Albani S, Martini A. Juvenile idiopathic arthritis. Lancet. 2011 Jun 18;377(9783):2138-49. doi: 10.1016/S0140-6736(11)60244-4.

  PMID: 21684384 BACKGROUND

• Milovanovic M, Nilsson E, Jaremo P. Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clin Chim Acta. 2004 May;343(1-2):237-40. doi: 10.1016/j.cccn.2003.12.030.

  PMID: 15115702 BACKGROUND

• Erre GL, Paliogiannis P, Castagna F, Mangoni AA, Carru C, Passiu G, Zinellu A. Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. Eur J Clin Invest. 2019 Jan;49(1):e13037. doi: 10.1111/eci.13037. Epub 2018 Nov 6.

  PMID: 30316204 BACKGROUND

MeSH Terms

Conditions

Arthritis, Juvenile

Interventions

Blood Cell Count

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Cell Count; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Hematologic Tests; Investigative Techniques; Cell Physiological Phenomena; Blood Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Central Study Contacts

Hadeer F Mohamed, resident

CONTACT

01030536331; hadeer.fadl@med.sohag.edu.eg

osama S Daifallah, AssistantProf

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident at rheumatology and rehabilitation department at sohag university hospitals

Study Record Dates

• First Submitted: June 27, 2025
• First Posted: July 24, 2025
• Study Start: July 15, 2025
• Primary Completion: April 15, 2026
• Study Completion: April 15, 2026
• Last Updated: July 24, 2025

Record last verified: 2025-06