Novel Predictors of Premature Aging in COPD Patients

NCT06019286 | Unknown

• 1 other identifier: premature aging in COPD
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

•Examine whether COPD is associated with accelerated aging using a biological marker of aging and dermatological score

Conditions

COPD

Keywords

premature aging

Outcome Measures

Primary Outcomes (3)

• SCINEXA score in relation to COPD patient chronological age.

  measuring SCINEXA score (Score for Intrinsic and Extrinsic skin Aging) in COPD patients and in control group and comparing it with chronological age. - 18 signs of extrinsic aging, each item will be scored as 0 (none), 1 (mild), 2 (moderate) or 3 (severe). For some items (uneven pigmentation, cutis rhomboidalis nuchae, elastosis, comedones and cysts of Favre Racouchot, and malignant skin tumors, a binary scale was used: (yes) or (no). Maximun possible score is 54

  1 week

• Level of GH and RDW in relation to COPD patient age.

  measuring level of GH and in COPD patients and control group

  1 week

• Comparing level of GH with the chronological age

  Compare level of GH with the chronological age of patients and controls to detected premature aging

  1 week

Study Arms (2)

COPD cases

COPD patients for whom biological marker and dermatological score will be measured

Diagnostic Test: SCINEXA score

Control group

non COPD subjects for whom biological marker and dermatological score will be measured

Diagnostic Test: SCINEXA score

Interventions

SCINEXA score DIAGNOSTIC_TEST

\- 18 signs of extrinsic aging of SCINEXA score: sunburn, freckles, actinic lentigo, hyperpigmentation and/or melasma, change in phototype, yellowness, pseudoscars, coarse wrinkles, solar elastosis, cutis rhomboidalis, elastosis, comedones and cysts of Favre-Racouchot, xerosis, teleangectasias, permanent erythema, actinic keratosis, basal cell carcinoma, squamous cell carcinoma and malignant melanoma (extrinsic SCINEXA score). Each item will be scored as 0 (none), 1 (mild), 2 (moderate) or 3 (severe). For some items (uneven pigmentation, cutis rhomboidalis nuchae, elastosis, comedones and cysts of Favre Racouchot, and malignant skin tumors, a binary scale was used: (yes) or (no). Maximun possible score is 54

Also known as: growth hormone level

COPD cases; Control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with COPD attending outpatient clinic either for follow up or newly diagnosed are eligible for inclusion as cases. Control group is non COPD healthy controls.

You may not qualify if:

• Patients refused to participate in the study.
• Patients unable to perform the spirometry test.
• Patients had a history of hormone disorder or malignant disease.
• Patients received hormone replacement therapy.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Brat K, Svoboda M, Zatloukal J, Plutinsky M, Volakova E, Popelkova P, Novotna B, Dvorak T, Koblizek V. Prognostic Properties of the GOLD 2023 Classification System. Int J Chron Obstruct Pulmon Dis. 2023 Apr 20;18:661-667. doi: 10.2147/COPD.S410372. eCollection 2023.

  PMID: 37114105 BACKGROUND

• Barnes PJ. Mechanisms of development of multimorbidity in the elderly. Eur Respir J. 2015 Mar;45(3):790-806. doi: 10.1183/09031936.00229714. Epub 2015 Jan 22.

  PMID: 25614163 BACKGROUND

• Jiang Z, Han X, Wang Y, Hou T, Dong Y, Han X, Welmer AK, Launer LJ, Du Y, Qiu C. Red cell distribution width, anemia, and lower-extremity physical function among rural-dwelling older adults. Aging Clin Exp Res. 2022 Oct;34(10):2483-2491. doi: 10.1007/s40520-022-02187-9. Epub 2022 Aug 9.

  PMID: 35943713 BACKGROUND

• Vierkotter A, Ranft U, Kramer U, Sugiri D, Reimann V, Krutmann J. The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing. J Dermatol Sci. 2009 Mar;53(3):207-11. doi: 10.1016/j.jdermsci.2008.10.001. Epub 2008 Dec 6.

  PMID: 19059763 BACKGROUND

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Aging, Premature

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Eman Fathy Ahmed, Dr.

  Assiut University

  STUDY CHAIR

• Heba Hassan Sayed, DR.

  Assiut University

  STUDY CHAIR

• Salma Mokhtar Osman, DR.

  Assiut University

  STUDY CHAIR

• Amal Adel Rayan, Dr.

  Assiut University

  STUDY CHAIR

Central Study Contacts

Sahar R Mahmoud, Dr.

CONTACT

01002866364; farida62014@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: August 19, 2023
• First Posted: August 31, 2023
• Study Start: September 1, 2023
• Primary Completion: March 1, 2024
• Study Completion: April 1, 2024
• Last Updated: August 31, 2023

Record last verified: 2023-08