QRS Microfragmentation in ECG as Predictor of Mortality and Morbidity - a Retrospective Analysis

NCT06011590 | Completed

• 1 other identifier: 1244/2022
• Study Type: observational
• Target: 150,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Over the past decades, several ECG-based parameters have been identified as independent predictors of worsened prognosis in affected patients. In addition to visual assessment of morphology, methods of computer-based machine ECG analysis have gained importance in recent years. These methods allow the detection of systemic abnormalities in ECGs that are not visible to the naked eye. An example of this is provided by the so-called "QRS microfragmentations". The aim of this evaluation is to retrospectively collect all established as well as new quantitative and qualitative ECG parameters (such as QRS microfragmentation) in a large patient collective. Subsequently, after characterization of the patients, an independent multivariate risk prediction model should be developed based on computer-based ECG analysis using maschnine learning algorithms.

Conditions

Risk Stratification

Outcome Measures

Primary Outcomes (1)

• All cause mortality

  Death of any cause

  between 01.01.2000 and 31.07.2022

Secondary Outcomes (2)

• Hospitalization

  between 01.01.2000 and 31.07.2022

• Lenght of hospital stay

  between 01.01.2000 and 31.07.2022

Study Arms (1)

Study Cohort

All patients treated at the Department of Internal Medicine at the Medical University of Innsbruck between 01.01.2000 and 31.07.2022, in whom a 10 second 12-lead ECG is available from clinical routine.

Other: No intervention.

Interventions

No intervention. OTHER

No intervention.

Study Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who presented to the Department of Internal Medicine at the Medical University in Innsbruck between 01.01.2000 and 31.07.2022 and received an ECG recording as part of routine clinical practice.

You may qualify if:

• Patients who presented to the Department of Internal Medicine at the Medical University in Innsbruck between 01.01.2000 and 31.07.2022 and received an ECG recording as part of routine clinical practice.
• Age ≥ 18 years
• Residence in Austria

You may not qualify if:

• Insuffizient ECG Recording quality

Sponsors & Collaborators

• Medical University Innsbruck: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2023
• First Posted: August 25, 2023
• Study Start: January 1, 2000
• Primary Completion: July 31, 2022
• Study Completion: July 31, 2022
• Last Updated: August 25, 2023

Record last verified: 2023-08