Cerebral Microdialysis in Patients With Fulminant Hepatic Failure

NCT00836420 | Completed

• 1 other identifier: KF 00/002
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with fulminant hepatic failure (FHF) often develop cerebral edema, high intracranial pressure (ICP)that may result in fatal brain damage. The aim in this protocol is to determine if a rise in the brain concentration of glutamate, lactate and pyruvate are involved in development of surges of high ICP in patients with FHF. The study is observatory in nature and also record the influence of any intervention that may e instituted during the course of the critical illness.

Conditions

Fulminant Hepatic Failure

Keywords

ammonia; acute liver failure; brain edema; oxidative metabolism; intracranial pressure

Outcome Measures

Primary Outcomes (1)

• Brain lactate concentration and intracranial hypertension

  to determine if brain oxidative metabolism correlates with brain edema and high intracranial pressure

  2013

Study Arms (1)

liver

patients with acute liver failure

Procedure: no intervention

Interventions

no intervention PROCEDURE

the value of the clinical use of microdialysis monitoring of the brain

liver

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

consecutive patients with fulminant hepatic failure

You may qualify if:

• All patients with fulminant hepatic failure

You may not qualify if:

• Age below 18 years
• Pregnancy
• Not obtained informed consent
• Suspicion of cancer disease
• No pupil reaction to light

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead

Study Sites (1)

Rigshospitalet Dept Hepatology A-2121

Copenhagen, 2100, Denmark

Location

Related Publications (4)

• Tofteng F, Jorgensen L, Hansen BA, Ott P, Kondrup J, Larsen FS. Cerebral microdialysis in patients with fulminant hepatic failure. Hepatology. 2002 Dec;36(6):1333-40. doi: 10.1053/jhep.2002.36944.

  PMID: 12447856 BACKGROUND

• Bjerring PN, Hauerberg J, Jorgensen L, Frederiksen HJ, Tofteng F, Hansen BA, Larsen FS. Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. J Hepatol. 2010 Dec;53(6):1054-8. doi: 10.1016/j.jhep.2010.05.032. Epub 2010 Aug 3.

  PMID: 20800925 BACKGROUND

• Bjerring PN, Hauerberg J, Frederiksen HJ, Jorgensen L, Hansen BA, Tofteng F, Larsen FS. Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. Neurocrit Care. 2008;9(1):3-7. doi: 10.1007/s12028-008-9060-4.

  PMID: 18250976 BACKGROUND

• Tofteng F, Hauerberg J, Hansen BA, Pedersen CB, Jorgensen L, Larsen FS. Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. J Cereb Blood Flow Metab. 2006 Jan;26(1):21-7. doi: 10.1038/sj.jcbfm.9600168.

  PMID: 15959460 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

microdialysate from the brain as part of rutine monitoring

MeSH Terms

Conditions

Liver Failure, Acute; Brain Edema

Condition Hierarchy (Ancestors)

Liver Failure; Hepatic Insufficiency; Liver Diseases; Digestive System Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Fin Stolze Larsen

  Rigshospitalet, Denmark

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: consultant

Study Record Dates

• First Submitted: February 3, 2009
• First Posted: February 4, 2009
• Study Start: January 1, 2000
• Primary Completion: October 1, 2015
• Study Completion: October 1, 2015
• Last Updated: October 27, 2015

Record last verified: 2015-10

Locations

DK (1)