Effect of Calisthenic Exercise Training Combined With Aerobic Exercise in Patients With Dyslipidemia

NCT06008912 | Completed

• 1 other identifier: KA-22027
• Study Type: interventional
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

Dyslipidemia is expressed as the serum concentration of lipid molecules with different structures outside the normal level. Deviation of serum lipid level from normal is accepted as the primary or most important factor in various cardiac and metabolic diseases, especially atherosclerosis. Dyslipidemia-related cardiovascular structure change is accepted as an important public health problem worldwide, and it is stated that the combined use of medical treatment, changes in diet and physical activity/structured exercise programs in the treatment of dyslipidemia is important in the success of treatment.

Conditions

Dyslipidemias

Keywords

Dyslipidemia; Calisthenic Exercise; Exercise Capacity

Outcome Measures

Primary Outcomes (1)

• Exercise Capacity

  Cardiopulmonary exercise capacity will assess as primary outcome measure, via cardiopulmonary exercise test (CPET).

  Second Day

Secondary Outcomes (9)

• Blood Lipids Concentration Assessment

  First Day

• Apolipoprotein A1 Concentration Assessment

  First Day

• Blood Sugar Concentration Assessment

  First Day

• C-reactive Protein Concentration Assessment

  First Day

• Sit-to-Stand Test

  First Day

Other Outcomes (1)

• Quality of Life Assessment

  Second Day

Study Arms (3)

Calisthenic + Aerobic Exercise Group

EXPERIMENTAL

Patients will take aerobic exercise training in 3 days per week, and 7 days per week calisthenic exercises for upper extremity, lower extremity and trunk, for 8 weeks.

Other: Calisthenic Exercises; Other: Aerobic Exercises

Aerobic Exercise Group

ACTIVE COMPARATOR

Patients will take aerobic exercise training in 3 days per week, for 8 weeks.

Other: Aerobic Exercises

Control Group

NO INTERVENTION

Patients will take physical activity recommendations, and just screening after 8 weeks.

Interventions

Calisthenic Exercises OTHER

Exercises for upper extremity, lower extremity and trunk which applying just patient's own body weight via using body mechanics. There is no need for any tools for exercises.

Calisthenic + Aerobic Exercise Group

Aerobic Exercises OTHER

Exercises which loading cardiovascular, respiratory and muscular system at the same time. Treadmill training will apply in the study.

Aerobic Exercise Group; Calisthenic + Aerobic Exercise Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Screening by the internal medicine clinic with the diagnosis of dyslipidemia
• Being between 18 to 65 years old
• Volunteering to participate in the research

You may not qualify if:

• Having any cardiac disease
• Having a co-existing psychiatric illness (like schizophrenia, bipolar disorder, etc.)
• Being infected with COVID-19 in the last 3 months
• Having any neurological problems that may affect cooperation
• Having pulmonary or orthopedic problem that may affect functional capacity

Sponsors & Collaborators

• Çankırı Karatekin University: lead
• Hacettepe University: collaborator

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

Related Publications (16)

• GBD 2015 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1659-1724. doi: 10.1016/S0140-6736(16)31679-8.

  PMID: 27733284 BACKGROUND

• Rivas-Gomez B, Almeda-Valdes P, Tussie-Luna MT, Aguilar-Salinas CA. DYSLIPIDEMIA IN MEXICO, A CALL FOR ACTION. Rev Invest Clin. 2018;70(5):211-216. doi: 10.24875/RIC.18002573.

  PMID: 30307444 BACKGROUND

• Pan L, Yang Z, Wu Y, Yin RX, Liao Y, Wang J, Gao B, Zhang L; China National Survey of Chronic Kidney Disease Working Group. The prevalence, awareness, treatment and control of dyslipidemia among adults in China. Atherosclerosis. 2016 May;248:2-9. doi: 10.1016/j.atherosclerosis.2016.02.006. Epub 2016 Feb 27.

  PMID: 26978581 BACKGROUND

• Zhang M, Deng Q, Wang L, Huang Z, Zhou M, Li Y, Zhao Z, Zhang Y, Wang L. Prevalence of dyslipidemia and achievement of low-density lipoprotein cholesterol targets in Chinese adults: A nationally representative survey of 163,641 adults. Int J Cardiol. 2018 Jun 1;260:196-203. doi: 10.1016/j.ijcard.2017.12.069.

  PMID: 29622441 BACKGROUND

• Yang F, Ma Q, Ma B, Jing W, Liu J, Guo M, Li J, Wang Z, Liu M. Dyslipidemia prevalence and trends among adult mental disorder inpatients in Beijing, 2005-2018: A longitudinal observational study. Asian J Psychiatr. 2021 Mar;57:102583. doi: 10.1016/j.ajp.2021.102583. Epub 2021 Feb 5.

  PMID: 33581368 BACKGROUND

• GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17;396(10258):1204-1222. doi: 10.1016/S0140-6736(20)30925-9.

  PMID: 33069326 BACKGROUND

• Tietge UJ. Hyperlipidemia and cardiovascular disease: inflammation, dyslipidemia, and atherosclerosis. Curr Opin Lipidol. 2014 Feb;25(1):94-5. doi: 10.1097/MOL.0000000000000051. No abstract available.

  PMID: 24398450 BACKGROUND

• Villarreal-Molina MT, Aguilar-Salinas CA, Rodriguez-Cruz M, Riano D, Villalobos-Comparan M, Coral-Vazquez R, Menjivar M, Yescas-Gomez P, Konigsoerg-Fainstein M, Romero-Hidalgo S, Tusie-Luna MT, Canizales-Quinteros S; Metabolic Study Group. The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. Diabetes. 2007 Jul;56(7):1881-7. doi: 10.2337/db06-0905. Epub 2007 Feb 7.

  PMID: 17287470 BACKGROUND

• Villarreal-Molina MT, Flores-Dorantes MT, Arellano-Campos O, Villalobos-Comparan M, Rodriguez-Cruz M, Miliar-Garcia A, Huertas-Vazquez A, Menjivar M, Romero-Hidalgo S, Wacher NH, Tusie-Luna MT, Cruz M, Aguilar-Salinas CA, Canizales-Quinteros S; Metabolic Study Group. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Diabetes. 2008 Feb;57(2):509-13. doi: 10.2337/db07-0484. Epub 2007 Nov 14.

  PMID: 18003760 BACKGROUND

• De Sousa SM Dr, Norman RJ Prof. Metabolic syndrome, diet and exercise. Best Pract Res Clin Obstet Gynaecol. 2016 Nov;37:140-151. doi: 10.1016/j.bpobgyn.2016.01.006. Epub 2016 Feb 10.

  PMID: 26972165 BACKGROUND

• Wang Y, Xu D. Effects of aerobic exercise on lipids and lipoproteins. Lipids Health Dis. 2017 Jul 5;16(1):132. doi: 10.1186/s12944-017-0515-5.

  PMID: 28679436 BACKGROUND

• Miles L. Physical activity and health. Nutr Bull [Internet]. 2007 Dec;32(4):314-63. Available from: http://doi.wiley.com/10.1111/j.1467-3010.2007.00668.x

  BACKGROUND

• Strunk RC, Mrazek DA, Fukuhara JT, Masterson J, Ludwick SK, LaBrecque JF. Cardiovascular fitness in children with asthma correlates with psychologic functioning of the child. Pediatrics. 1989 Sep;84(3):460-4.

  PMID: 2771549 BACKGROUND

• Carson KV, Chandratilleke MG, Picot J, Brinn MP, Esterman AJ, Smith BJ. Physical training for asthma. Cochrane Database Syst Rev. 2013 Sep 30;2013(9):CD001116. doi: 10.1002/14651858.CD001116.pub4.

  PMID: 24085631 BACKGROUND

• Eime RM, Young JA, Harvey JT, Charity MJ, Payne WR. A systematic review of the psychological and social benefits of participation in sport for children and adolescents: informing development of a conceptual model of health through sport. Int J Behav Nutr Phys Act. 2013 Aug 15;10:98. doi: 10.1186/1479-5868-10-98.

  PMID: 23945179 BACKGROUND

• Ozdemir F, Saglam M, Aksel Uylar AA, Uyaroglu OA, Basaran NC, Tanriover MD, Yagli NV. Could calisthenic exercises improve maximal exercise capacity, peripheral muscle strength and quality of life in dyslipidemia? PLoS One. 2025 Jun 17;20(6):e0326026. doi: 10.1371/journal.pone.0326026. eCollection 2025.

  PMID: 40526594 DERIVED

MeSH Terms

Conditions

Dyslipidemias

Interventions

Exercise

Condition Hierarchy (Ancestors)

Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Masking Details: Patients and his/her caregivers will allocate in study via computer based randomisation, and will not know about his/her and also other participants group in study.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Model Details: Experimental model of study consist from three arm. * First Arm: Patients will take aerobic exercise training in 3 days per week, and 7 days per week calisthenic exercises for upper extremity, lower extremity and trunk, for 8 weeks. * Second Arm: Patients will take aerobic exercise training in 3 days per week, for 8 weeks. * Third Arm: Patients will take physical activity recommendations, and just screening after 8 weeks.

Study Record Dates

• First Submitted: August 8, 2023
• First Posted: August 24, 2023
• Study Start: May 14, 2023
• Primary Completion: July 31, 2024
• Study Completion: December 1, 2024
• Last Updated: December 31, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)