AYAHIV Role-based Responsibilities for Oncology-focused Workforce (ARROW)
Integrated Delivery of Cancer Control Interventions for Adolescents and Young Adults Living With HIV in Zambia
1 other identifier
interventional
4,100
1 country
1
Brief Summary
Adolescents and young adults living with HIV experience higher premature mortality from cancer than their uninfected peers. In Zambia, because of multilevel barriers, interventions for early diagnosis and optimized treatment to reduce this cancer mortality are underutilized for this disproportionally impacted cohort. In this study, the investigators will test peer-to-peer education and support strategies to increase use of early diagnosis services in HIV treatment facilities and improve compliance with cancer treatment in the cancer center.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2024
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 15, 2023
CompletedFirst Posted
Study publicly available on registry
August 22, 2023
CompletedStudy Start
First participant enrolled
May 1, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 31, 2027
January 15, 2026
January 1, 2026
2.3 years
August 15, 2023
January 13, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Proportion who complete screening/physical examination
Number who complete screening/physician exams
12 months after study enrollment
Proportion who complete recommended cancer treatment modalities
Number who complete treatment
12 months after diagnosis
Secondary Outcomes (3)
Proportion who complete recommended follow-up supplemental diagnostic procedures
3 months from receipt of follow-up referral
Proportion who initiate cancer treatment
3 months from diagnosis
Proportion alive at 12 months
12 months after diagnosis
Study Arms (2)
ARROW strategies
EXPERIMENTALThe ARROW strategies which use peer-peer support at the patient level (through peer counselors), at the provider level (through peer lead education sessions) and at the health system level (through a health collaborative forum) to deliver high quality screenings and ensure cancer treatment completion.
One-time education
ACTIVE COMPARATORThe comparator arm participants will receive one-time education and usual care services.
Interventions
ARROW strategies are peer-to-peer support at the patient, provider and health system levels
The comparison group will receive a one-time education campaign that will provide informational brochures to adolescents and young adults living with HIV and HIV providers
Eligibility Criteria
You may qualify if:
- to 39 years of age at the time of study enrolment, on antiretroviral medication (ART) for at least 6 months and with no pending plans to move from current residence during the 3-year study duration
You may not qualify if:
- pregnant at study enrolment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Implenomicslead
- Population Councilcollaborator
- RTI Internationalcollaborator
Study Sites (1)
Public Health Facilities
Lusaka, Zambia
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 15, 2023
First Posted
August 22, 2023
Study Start
May 1, 2024
Primary Completion (Estimated)
August 31, 2026
Study Completion (Estimated)
July 31, 2027
Last Updated
January 15, 2026
Record last verified: 2026-01