NCT05997407

Brief Summary

The goal of this clinical trial is to test the effect of a mindset management intervention on stress levels in women with infertility. The main question it aims to answer is: Can the Organic Conceptions approach decrease stress levels in women with infertility? Participants in both groups will be asked to complete three surveys at three time points. The intervention group will complete the Organic Conceptions program, while the control group will not complete an intervention. Researchers will compare the intervention group and control group to see if the Organic Conceptions mindset management program decreases stress levels in women with infertility.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
66

participants targeted

Target at P50-P75 for not_applicable

Timeline
7mo left

Started Nov 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress81%
Nov 2023Dec 2026

First Submitted

Initial submission to the registry

July 26, 2023

Completed
23 days until next milestone

First Posted

Study publicly available on registry

August 18, 2023

Completed
3 months until next milestone

Study Start

First participant enrolled

November 10, 2023

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

September 10, 2025

Status Verified

August 1, 2025

Enrollment Period

3.1 years

First QC Date

July 26, 2023

Last Update Submit

September 3, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Stress levels in women with infertility

    Measured by responses to the Copenhagen Multi-center Psychosocial Infertility Fertility Problem Stress Scale Minimum value: 14 Maximum value: 66 Higher score means higher stress level due to infertility, and a potentially worse outcome

    Day 0, end of week 10 (day 70), end of week 16 (day 112)

Secondary Outcomes (7)

  • Comparison of number of participants in each study group who returned for follow-up appointment within 6 months of initial consultation

    Within 6 months of initial consultation

  • Comparison of number of participants in each study group who began fertility treatment within 6 months of follow-up appointment

    Within 6 months of follow-up appointment

  • Comparison of number of participants in each study group who completed fertility treatment

    Recorded immediately after fertility treatment (IVF, ovulation induction, etc) is completed. Depends upon the treatment and what the provider indicates the treatment path should be

  • Pregnancy rates

    Study period (16 weeks) + 1 year

  • Satisfaction with Organic Conceptions intervention

    End of week 10 (day 70), end of week 16 (day 112). Intervention group only.

  • +2 more secondary outcomes

Study Arms (2)

Organic Conceptions intervention group

EXPERIMENTAL

Will complete Organic Conceptions intervention.

Behavioral: Organic Conceptions mindset management program

Control group

NO INTERVENTION

Will not complete Organic Conceptions intervention.

Interventions

Organic Conceptions is a theoretical model and corresponding 9-step cognitive-based therapy program that enables people to understand where they are in their fertility journey, and provides them with coping strategies to reframe the painful emotional side effects of infertility. In addition to the 9-step program, there are mini-classes on the key triggers that people face when dealing with infertility. The intervention consists of a series of assignments that participants in the intervention group will complete for a ten-week period. These assignments will take approximately three hours per week to complete. In addition, participants will complete biweekly live support group sessions led by certified coaches and will have the option to join a Facebook support group.

Organic Conceptions intervention group

Eligibility Criteria

Age18 Years - 42 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Speaks and reads English
  • New patient at Shady Grove Fertility in Roanoke or Richmond
  • Access to smartphone, tablet, or computer, and internet

You may not qualify if:

  • Has seen a fertility specialist (reproductive endocrinologist) before AND underwent fertility treatment under that provider
  • Is currently engaging with the Organic Conceptions method

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Shady Grove Fertility

Roanoke, Virginia, 24018, United States

RECRUITING

MeSH Terms

Conditions

Infertility, Female

Condition Hierarchy (Ancestors)

Genital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital DiseasesInfertility

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

July 26, 2023

First Posted

August 18, 2023

Study Start

November 10, 2023

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

September 10, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share

Locations