The Relationship of DASH and Mediterranean Diet Score With Serum Adiponectin Levels in Patients With Spinal Cord Injury

NCT05997251 | Completed

• 1 other identifier: E2-21-89
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to reveal the relationship of DASH and Mediterranean diet score with anthropometric measurements and serum adiponectin level in individuals with spinal cord injury. This research was planned as a cross-sectional, case-control study. With the data to be obtained from the research, information will be obtained about the hormonal or biochemical basis of metabolic disorders such as atherosclerosis and insulin resistance that may occur in individuals with spinal cord injury in the long term. 20 individuals with Spinal Cord Injury will be included in the study, and the results of the patients will be compared with 20 healthy individuals. In order to determine the food consumption status of the patients, a 1-day food consumption record will be requested. DASH diet score and Mediterranean diet score will be calculated from dietary records. After 8 hours of fasting, 3 ml of peripheral blood will be taken for the measurement of adiponectin between 08:00 and 09:00 in the morning from the individuals in the study and control groups. Adiponectin level will be measured and its correlation with DASH diet score and Mediterranean diet score will be examined.

Conditions

Spinal Cord Injuries

Keywords

Adiponectin

Outcome Measures

Primary Outcomes (3)

• Adiponectin level

  Adiponectin level will be measured from peripheral blood

  Will be measured at inclusion

• DASH diet score

  Will be measured at inclusion from one day dietary record

  Will be measured at inclusion from one day dietary record

• Mediterrenian diet score

  Will be measured at inclusion from one day dietary record

  Will be measured at inclusion from one day dietary record

Secondary Outcomes (6)

• Whole blood count

  Will be measured at inclusion

• Fasting blood glucose

  Will be measured at inclusion

• Total cholesterol

  Will be measured at inclusion

• LDL

  Will be measured at inclusion

• HDL

  Will be measured at inclusion

Study Arms (2)

Patients with spinal cord injury

Other: Keeping a 1-day food consumption record by the patient; Other: Measurement of adiponectin level

Healthy group

Other: Keeping a 1-day food consumption record by the patient; Other: Measurement of adiponectin level

Interventions

Keeping a 1-day food consumption record by the patient OTHER

Checking and receiving the 1-day food consumption record recorded by the patient by the researcher

Healthy group; Patients with spinal cord injury

Measurement of adiponectin level OTHER

Adiponectin level will be measured for each group

Healthy group; Patients with spinal cord injury

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients admitted to hospital Healthy population from patient care givers of hospital staff

You may qualify if:

• Having spent at least 6 months after spinal cord injury
• st motor neuron injury
• Being between the ages of 18-65
• Being between the ages of 18-65
• Giving consent to participate in the study

You may not qualify if:

• Having an additional disease to the spinal cord injury
• Having a 2nd motor neuron lesion
• Having any disease

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital Physical Treatment and Rehabilitation Hospital

Ankara, Turkey (Türkiye)

Location

Related Publications (3)

• Wang YH, Huang TS, Liang HW, Su TC, Chen SY, Wang TD. Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Arch Phys Med Rehabil. 2005 Oct;86(10):1964-8. doi: 10.1016/j.apmr.2005.04.017.

  PMID: 16213239 BACKGROUND

• Ekmekci H, Ekmekci OB. The role of adiponectin in atherosclerosis and thrombosis. Clin Appl Thromb Hemost. 2006 Apr;12(2):163-8. doi: 10.1177/107602960601200203.

  PMID: 16708117 BACKGROUND

• O'Brien LC, Graham ZA, Chen Q, Lesnefsky EJ, Cardozo C, Gorgey AS. Plasma adiponectin levels are correlated with body composition, metabolic profiles, and mitochondrial markers in individuals with chronic spinal cord injury. Spinal Cord. 2018 Sep;56(9):863-872. doi: 10.1038/s41393-018-0089-8. Epub 2018 Mar 20.

  PMID: 29559683 BACKGROUND

MeSH Terms

Conditions

Spinal Cord Injuries

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: August 10, 2023
• First Posted: August 18, 2023
• Study Start: March 1, 2021
• Primary Completion: March 1, 2022
• Study Completion: March 1, 2022
• Last Updated: August 18, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)