Reciprocal Inhibition Versus Reciprocal Facilitation In Spinal Cord Injury Patients

NCT05985031 | Completed

• 1 other identifier: RIVRFSCIP
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Reciprocal inhibition is a medulla spinalis control mechanism that facilitates motor activities in healthy people. As the agonist muscle contracts, the antagonist muscle is inhibited so that the agonist action can take place properly. In the literature, there are studies showing that in patients with upper motor neuron lesions, this reverses, and reciprocal facilitation occurs instead of inhibition. However, there is no clear situation in this regard, there is a need for more methodologically sound studies. Our aim in this study is to investigate the presence of reciprocal facilitation in patients with spinal cord lesions (SCL).

Conditions

Spinal Cord Injuries

Keywords

Spinal Cord; motor neuron; Spasticity

Outcome Measures

Primary Outcomes (1)

• Reciprocal Inhibition

  H reflex and T reflex tests were performed in the soleus and tibialis anterior muscle, and it was evaluated whether there was reciprocal inhibition in the tibialis anterior muscle.

  up to 2 weeks

Secondary Outcomes (2)

• H-reflex

  up to 2 weeks

• T-reflex

  up to 2 weeks

Study Arms (2)

Spinal cord injuries

EXPERIMENTAL

This was the patient group. Achilles tendon hits were performed for eliciting the soleus T reflex while the ankle was in neutral, dorsiflexion, and plantar flexion. Surface and multi-unit EMG recordings were taken from the anterior and soles muscles of the tibialis during the tendon tapping.

Diagnostic Test: Tendon tap; Diagnostic Test: Tibial nerve stimulation

Healthy Control

ACTIVE COMPARATOR

This was the healthy control group. Achilles tendon hits were performed for eliciting the soleus T reflex while the ankle was in neutral, dorsiflexion, and plantar flexion. Surface and multi-unit EMG recordings were taken from the anterior and soles muscles of the tibialis during the tendon tapping.

Diagnostic Test: Tendon tap; Diagnostic Test: Tibial nerve stimulation

Interventions

Tendon tap DIAGNOSTIC_TEST

While examining the T reflex, the ankle was held passively in neutral, dorsiflexion and plantar flexion positions by the investigator.

Also known as: T-reflex

Healthy Control; Spinal cord injuries

Tibial nerve stimulation DIAGNOSTIC_TEST

H-reflex responses were examined by tibial nerve stimulation

Also known as: H-reflex

Healthy Control; Spinal cord injuries

Eligibility Criteria

• Age: 25 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with spinal cord injury between the ages of 18-60
• A minimum of 6 months of SCL history
• Soleus spasticity

You may not qualify if:

• Patients with premorbid neuromuscular disease
• History of autonomic dysreflexia
• Patients in the spinal shock period
• Those who have a coronavirus disease clinic
• Less than 2 hours sitting tolerance

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

İstanbul Physical Therapy Training and Research Hospital

Istanbul, 34180, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Spinal Cord Injuries; Muscle Spasticity

Interventions

H-Reflex

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries; Muscular Diseases; Musculoskeletal Diseases; Muscle Hypertonia; Neuromuscular Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Reflex, Monosynaptic; Reflex; Nervous System Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• İLHAN KARACAN, MD, Prof

  İstanbul Physical Therapy Rehabilitation Training & Research Hosptial

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant doctor

Model Details: Group I. Spinal cord injuries Group II. Healthy Control

Study Record Dates

• First Submitted: August 2, 2023
• First Posted: August 14, 2023
• Study Start: January 5, 2023
• Primary Completion: January 17, 2023
• Study Completion: August 1, 2023
• Last Updated: August 15, 2023

Record last verified: 2023-08

Locations

TU (1)