Nano Fat Injection With or Without Fractional Carbon Dioxide Laser in Acne Scars

NCT05985265 | Unknown DMC

• 1 other identifier: nano fat injection
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Assessment of nano fat grafting combined with carbon dioxide laser resurfacing versus nano fat grafting alone in treating facial atrophic acne scars

Conditions

Acne Scars - Atrophic

Outcome Measures

Primary Outcomes (1)

• Clinical assessment of acne scar severity

  as assessed using the Goodman and Baron Qualitative scar grading system before and after treatment on both sides of face, to determine the number of patients achieving two grades improvement vs one grade or no improvement

  up to 24 weeks

Secondary Outcomes (4)

• Physician global assessment

  up to 24 weeks

• percent of reduction in scar count

  up to 24 weeks

• Patient satisfaction

  1 year

• Adverse events

  1 year

Study Arms (1)

Nano fat grafting and fractional carbon dioxide laser resurfacing

EXPERIMENTAL

treating of atrophic acne scars with nano fat and fractional carbon dioxide laser

Procedure: Fat grafting

Interventions

Fat grafting PROCEDURE

Nano fat grafting followed by fractional carbon dioxide laser resurfacing

Also known as: fractional carbon dioxide laser resurfacing

Nano fat grafting and fractional carbon dioxide laser resurfacing

Eligibility Criteria

• Age: 16 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• patients older than 18 years who attend the Outpatient Clinics of Dermatology and Plastic Surgery Departments, Assiut University Hospital, with moderate to severe atrophic facial acne scars on both cheeks, as assessed using the Goodman and Baron Qualitative scar grading system (12), will be enrolled in the study.

You may not qualify if:

• include: pregnancy or lactation; active acne, history of deep chemical peeling or filler injection in the previous 6 months, history of keloid or hypertrophic scar formation; use of isotretinoin in the previous 6 months; active infection in the treatment area; bleeding tendencies; history of herpes simplex or herpes zoster infection on the face; and patients with unrealistic expectations.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Faculty of Medicine, Assiut University

Asyut, 71111, Egypt

Location

Related Publications (3)

• Goodman GJ, Baron JA. Postacne scarring: a qualitative global scarring grading system. Dermatol Surg. 2006 Dec;32(12):1458-66. doi: 10.1111/j.1524-4725.2006.32354.x.

  PMID: 17199653 BACKGROUND

• Jacob CI, Dover JS, Kaminer MS. Acne scarring: a classification system and review of treatment options. J Am Acad Dermatol. 2001 Jul;45(1):109-17. doi: 10.1067/mjd.2001.113451.

  PMID: 11423843 RESULT

• Chan NP, Ho SG, Yeung CK, Shek SY, Chan HH. Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians. Lasers Surg Med. 2010 Nov;42(9):615-23. doi: 10.1002/lsm.20974.

  PMID: 20976801 RESULT

Study Officials

• youssef S farrag, MD

  Department of Plastic Surgery, professor

  PRINCIPAL INVESTIGATOR

• Wael S Ibraheem, MD

  Department of Plastic Surgery , Assistant lecture

  PRINCIPAL INVESTIGATOR

Central Study Contacts

mohammed H Abdelhafez, MBBS

CONTACT

+201099068855; Dr.m.zayan@gmail.com

sara M Awad, MD

CONTACT

+201023102094; saramawad@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident plastic surgery department

Study Record Dates

• First Submitted: November 15, 2022
• First Posted: August 14, 2023
• Study Start: September 1, 2023
• Primary Completion: April 29, 2024
• Study Completion: May 29, 2024
• Last Updated: August 14, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)