CXCL2/CXCL8 Promote Intervertebral Disc Degeneration
Study on the Correlation Between CXCL2/CXCL8 and the Degree of Intervertebral Disc Degeneration and Radiological Progress
1 other identifier
observational
40
1 country
1
Brief Summary
Low back pain (LBP) is the largest cause of morbidity in the world, and about 80% of Chinese people are affected in their lifetime. Although the prevalence of IDD gradually increases with age, IDD is very common among subjects under 30 years old. In addition to age, there are other factors, such as excessive or uneven mechanical load, obesity, genetics, nutrition, trauma and gender. In addition, it is not clear whether the heavy physical load associated with occupation is an important risk factor for IDD. Some studies have found that IDD is more common among athletes than the general population. Due to the complexity and multifactorial nature of IDD, its pathogenesis and risk factors are still unclear, which seriously hinders the rational stratification of LBP patients and limits the development of personalized treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Aug 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 19, 2023
CompletedStudy Start
First participant enrolled
August 1, 2023
CompletedFirst Posted
Study publicly available on registry
August 4, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 30, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
March 30, 2024
CompletedAugust 4, 2023
July 1, 2023
8 months
February 19, 2023
July 28, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
CXCL2/8 content
CXCL2/CXCL8 content of nucleus pulposus
1 month
Study Arms (4)
pirffmann 2 grade
pirffmann 3 grade
pirffmann 4 grade
pirffmann 5 grade
Interventions
Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group
Eligibility Criteria
Patients with lumbar disc herniation who went to the spinal surgery department of Zhongda Hospital
You may qualify if:
- It meets the diagnostic criteria of lumbar disc degeneration; No previous history of spinal surgery; Good ability of independent behavior and cooperation in completing research; The patient is aware of this study and has signed the consent form.
You may not qualify if:
- Patients with spinal tumor, infection, tuberculosis and other diseases; Patients with claustrophobia; Parkinson's syndrome patients; Poor cooperation, Poor image quality; Patients with osteoporosis.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Zhongda Hospitallead
Study Sites (1)
Zhongda Hospital
Nanjing, Jiangsu, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
February 19, 2023
First Posted
August 4, 2023
Study Start
August 1, 2023
Primary Completion
March 30, 2024
Study Completion
March 30, 2024
Last Updated
August 4, 2023
Record last verified: 2023-07
Data Sharing
- IPD Sharing
- Will not share