Nationwide Trends in Incidence, Healthcare Utilization, and Mortality in Hospitalized Acute Myocardial Infarction Patients in Taiwan

NCT05974397 | Completed

• 1 other identifier: CLCZ696BTW05
• Study Type: observational
• Target: 124,018
• Locations: 1 country
• Sites: 1

Brief Summary

This was a retrospective study using the Taiwan's National Health Insurance Research Database (NHIRD). The study employed two study designs for different purposes as follows:

• A cross-sectional analysis was conducted to explore the annual incidence trends.
• A longitudinal cohort study was conducted to assess baseline characteristics, treatment patterns, long-term healthcare utilization, and cause-specific mortality among incident AMI patients. In each part, the study was conducted for AMI, and separately for ST-segment elevation and non-ST- segment elevation myocardial infarction (STEMI and NSTEMI)

Conditions

Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (30)

• Mean age of patients

  12 months

• Number of male patients

  12 months

• Year of patient entry into cohort

  12 months

• Number of patients with AMI in Taiwan

  12 months

• Number of patients with STEMI in Taiwan

  12 months

• Number of patients with NSTEMI in Taiwan

  12 months

• Number of AMI patients with comorbidities

  Up to 3 years

• Number of patients with treatment for AMI

  Up to 3 years

• Number of STEMI patients with comorbidities

  Up to 3 years

• Number of patients with treatment for STEMI

  Up to 3 years

• Number of NSTEMI patients with comorbidities

  Up to 3 years

• Number of patients with treatment for NSTEMI

  Up to 3 years

• Number of mortalities among AMI patients

  Up to 3 years

• Number of mortalities among STEMI patients

  Up to 3 years

• Number of mortalities among NSTEMI patients

  Up to 3 years

• Number of AMI patients with outpatient visits

  Up to 3 years

• Number of AMI patients with emergency room visits

  Up to 3 years

• Number of AMI patients with hospitalizations

  Up to 3 years

• Length of hospital stay for AMI patients

  Up to 3 years

• Direct medical costs for AMI patients

  Up to 3 years

• Number of STEMI patients with outpatient visits

  Up to 3 years

• Number of STEMI patients with emergency room visits

  Up to 3 years

• Number of STEMI patients with hospitalizations

  Up to 3 years

• Length of hospital stay for STEMI patients

  Up to 3 years

• Direct medical costs for STEMI patients

  Up to 3 years

• Number of NSTEMI patients with outpatient visits

  Up to 3 years

• Number of NSTEMI patients with emergency room visits

  Up to 3 years

• Number of NSTEMI patients with hospitalizations

  Up to 3 years

• Length of hospital stay for NSTEMI patients

  Up to 3 years

• Direct medical costs for NSTEMI patients

  Up to 3 years

Study Arms (3)

AMI

Patients with AMI

STEMI

Patients with STEMI

NSTEMI

Patients with NSTEMI

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This was a retrospective, noninterventional cohort study.

You may qualify if:

• Cross-sectional analysis:
• Patients aged 20 years and older.
• Patients who had been admitted for AMI, defined as primary or first secondary diagnosis of AMI between 2014 and 2020.
• The diagnosis of AMI/ STEMI/ NSTEMI was identified by the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes and 10th revision (ICD-10-CM) codes.
• Incident cases of AMI hospitalization were defined as no history of AMI-related hospitalization or outpatient visit within 1 year before admission.
• Longitudinal analysis:
• Patients aged 20 years and older.
• Patients who had been admitted for AMI, defined as primary or first secondary diagnosis of AMI between 2014 and 2017.
• The diagnosis of AMI/ STEMI/ NSTEMI was identified by ICD-9-CM codes and ICD-10-CM codes. (The ICD-9-CM code and ICD-10-CM codes were the same as above)
• Incident cases of AMI hospitalization were defined as no history of AMI-related hospitalization or outpatient visit within 1 year before admission.
• The cohort entry date was defined as the admission date of incident AMI hospitalization, and the index date was defined as the discharge date of incident hospitalization.

You may not qualify if:

• None specified

Sponsors & Collaborators

• Novartis Pharmaceuticals: lead

Study Sites (1)

Novartis

Taipei, Taiwan

Location

Study Officials

• Novartis Pharmaceuticals

  Novartis Pharmaceuticals

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2023
• First Posted: August 3, 2023
• Study Start: September 30, 2021
• Primary Completion: July 22, 2022
• Study Completion: July 22, 2022
• Last Updated: August 3, 2023

Record last verified: 2023-07

Locations

TW (1)