Prognostic Value of Right Ventricular Myocardial Strain in Patients With Acute Myocardial Infarction

NCT05404555 | Unknown

• 1 other identifier: M2022093
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

For a long time, the right ventricle has been the "forgotten chamber", but with the deepening of people's understanding of the disease, right ventricular dysfunction has become an important factor to evaluate the disease progression and late prognosis of patients with AMI. Right ventricular myocardial strain derived from two-dimensional speckle tracking echocardiography is a new method for early evaluation of regional and global right ventricular systolic function, and its repeatability is much higher than that of LVEF. Acute inferior myocardial infarction is often caused by occlusion of the proximal middle segment of the right coronary artery. Many studies have confirmed that RVMS is an independent predictor of poor prognosis in patients with AIMI. However, 60% of the right ventricular systolic function is contributed by the left ventricle and interventricular septum, and the left anterior descending branch and the left circumflex branch are the main sources of blood supply to the left ventricle and interventricular septum, so in theory, non-RCA occlusion can also lead to varying degrees of right ventricular dysfunction. However, there are few studies on the role of RVMS in predicting the prognosis of AMI patients caused by non-RCA occlusion. Therefore, the purpose of this study is to prospectively study the value of dynamic changes of RVMS in predicting the prognosis of patients with acute myocardial infarction with different infarct-related vessels, in order to provide more clinical reference information for the diagnosis and treatment of AMI.

Conditions

Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Major Adverse Cardiovascular Events

  Nonfatal stroke, nonfatal myocardial infarction, target vessel requiring revascularization, death

  2 years

Study Arms (2)

acute myocardia infarction patients with right coronary artery occlusion

Other: two-dimensional speckle tracking echocardiography

acute myocardia infarction patients with non-right coronary artery occlusion

Other: two-dimensional speckle tracking echocardiography

Interventions

two-dimensional speckle tracking echocardiography OTHER

Two-dimensional speckle tracking echocardiography is used to assess cardiac function in all enrolled patients

acute myocardia infarction patients with non-right coronary artery occlusion; acute myocardia infarction patients with right coronary artery occlusion

Eligibility Criteria

• Age: 35 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients with acute myocardial infarction undergoing primary percutaneous coronary intervention are included.

You may qualify if:

• Males and females were between 35 and 85 years old;
• coronary artery disease underwent emergency PCI for NSTEMI or primary PCI for STEMI;
• coronary artery type was right coronary dominance;
• regular follow-up for 2 year.

You may not qualify if:

• Patients who cannot complete 2D speckle tracking imaging;
• patients with severe valvular disease, cardiomyopathy, or congenital heart disease; severe liver and kidney insufficiency or chronic respiratory disease;
• previous PCI or CABG;
• coronary artery type: Left crown dominance.

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

RECRUITING

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 31, 2022
• First Posted: June 3, 2022
• Study Start: October 1, 2021
• Primary Completion: May 30, 2024
• Study Completion: October 30, 2024
• Last Updated: June 24, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)