High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners

NCT05951985 | Completed

• 1 other identifier: ACHE-2023-0114
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Individuals with and without neurologic diagnoses greatly benefit from participation in regular exercise but the majority are physically inactive. This is an issue for both them and their care partners as their health is often linked. This study aims to examine the long-term physical and psychosocial effects of structured, group-based, high intensity functional training (HIFT) exercise for people with neurologic diagnoses and their care partners.

Conditions

Neurologic Disorder; Parkinson Disease; Spinal Cord Injuries; Spina Bifida; Stroke; Poliomyelitis; Multiple Sclerosis; Brain Injuries

Keywords

hift; exercise

Outcome Measures

Primary Outcomes (1)

• Participant Attendance at 24 months

  The percentage of intervention sessions attended by participants.

  After 24 months of intervention

Secondary Outcomes (24)

• Change in lower extremity functional strength at 24 months

  After, 3, 6, 9, 12, 15, 18, 21 and 24 months of intervention

• hange in Parkinson's Disease Questionnaire - 39 (PDQ-39) at 24 months

  After, 3, 6, 9, 12, 15, 18, 21 and 24 months of intervention

• Change in fast-paced gait speed at 24 months

  After, 3, 6, 9, 12, 15, 18, 21 and 24 months of intervention

• Change in fast-paced wheelchair propulsion speed at 24 months

  After, 3, 6, 9, 12, 15, 18, 21 and 24 months of intervention

• Change in 6 Minute Walk Test at 24 months

  After, 3, 6, 9, 12, 15, 18, 21 and 24 months of intervention

Study Arms (1)

HIFT Exercise

EXPERIMENTAL

In this single group design, all participants will be provided with up to two years of twice weekly supervised group exercise.

Behavioral: HIFT

Interventions

HIFT BEHAVIORAL

Exercise sessions will be 60 to 75 minutes in duration and be a combination of resistance, aerobic, and balance exercise, with emphasis on functional movements performed at a high intensity. Exercises will be tailored/modified to meet the needs of each participant.

HIFT Exercise

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants must be at least 18 years of age
• Participants must be able to communicate and read in English
• Participants must have physician and/or advanced practice provider clearance to exercise
• Participants must have a neurologic diagnosis (e.g., spinal cord injury, Parkinson's, brain injury, stroke, poliomyelitis, multiple sclerosis, spina bifida, etc.) OR participants must be care partner of a person with neurologic diagnosis.
• Participants must possess at least 4/5 elbow flexion strength bilaterally
• Participants must be able to locomote independently (i.e., ambulate or propel a manual or power wheelchair independently).
• Participants must provide their own transportation to/from the research study

Sponsors & Collaborators

• Arkansas Colleges of Health Education: lead

Study Sites (1)

Arkansas Colleges of Health Education

Fort Smith, Arkansas, 72916, United States

Location

Related Publications (4)

• Schenkman M, Moore CG, Kohrt WM, Hall DA, Delitto A, Comella CL, Josbeno DA, Christiansen CL, Berman BD, Kluger BM, Melanson EL, Jain S, Robichaud JA, Poon C, Corcos DM. Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2018 Feb 1;75(2):219-226. doi: 10.1001/jamaneurol.2017.3517.

  PMID: 29228079 BACKGROUND

• Ellis TD, Cavanaugh JT, DeAngelis T, Hendron K, Thomas CA, Saint-Hilaire M, Pencina K, Latham NK. Comparative Effectiveness of mHealth-Supported Exercise Compared With Exercise Alone for People With Parkinson Disease: Randomized Controlled Pilot Study. Phys Ther. 2019 Feb 1;99(2):203-216. doi: 10.1093/ptj/pzy131.

  PMID: 30715489 BACKGROUND

• Feito Y, Heinrich KM, Butcher SJ, Poston WSC. High-Intensity Functional Training (HIFT): Definition and Research Implications for Improved Fitness. Sports (Basel). 2018 Aug 7;6(3):76. doi: 10.3390/sports6030076.

  PMID: 30087252 BACKGROUND

• Adams J, Lai B, Rimmer J, Powell D, Yarar-Fisher C, Oster RA, Fisher G. Telehealth high-intensity interval exercise and cardiometabolic health in spinal cord injury. Trials. 2022 Aug 4;23(1):633. doi: 10.1186/s13063-022-06585-2.

  PMID: 35927708 BACKGROUND

MeSH Terms

Conditions

Nervous System Diseases; Parkinson Disease; Spinal Cord Injuries; Spinal Dysraphism; Stroke; Poliomyelitis; Multiple Sclerosis; Brain Injuries; Motor Activity

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Spinal Cord Diseases; Trauma, Nervous System; Wounds and Injuries; Neural Tube Defects; Nervous System Malformations; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cerebrovascular Disorders; Vascular Diseases; Cardiovascular Diseases; Myelitis; Central Nervous System Infections; Infections; Enterovirus Infections; Picornaviridae Infections; RNA Virus Infections; Virus Diseases; Neuroinflammatory Diseases; Neuromuscular Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Craniocerebral Trauma; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Longitudinal with assessments occurring quarterly over the course of two years

Study Record Dates

• First Submitted: July 11, 2023
• First Posted: July 19, 2023
• Study Start: August 15, 2023
• Primary Completion: July 14, 2025
• Study Completion: August 14, 2025
• Last Updated: August 22, 2025

Record last verified: 2025-08

Locations

US (1)