NCT03969927

Brief Summary

The use of simulators to retrain driving skills of patients with stroke, Parkinson's disease (PD), or multiple sclerosis (MS) is very limited because of cost, space required, and incidence of simulator sickness in high fidelity simulators. The Principal investigator recently developed a low cost low fidelity portable driving simulator (PDS). In this pilot study, the study team will (1) determine the ease of use and occurrence of simulator sickness while operating the low fidelity PDS in a clinic setting and (2) the efficacy of the low fidelity PDS to reproduce the benefits from retraining impaired driving skills of stroke survivors in a high-fidelity simulator. Participants: 30 participants, separated according to neurological condition including stroke, PD, or MS, will be randomly allocated to either the PDS or fixed-base high-fidelity simulator training. Each participant will undergo a pre-training evaluation, five hours of designated training and a post-training assessment, similar to the pre-training evaluation. Data will be analyzed according to study aims. The investigators hypothesize that the simple set up of the PDS will make it easier to use and better decrease the incidence of simulator sickness that typically leads to stopping therapy than the high-fidelity simulator. The investigators hypothesize that improvements in lane maintenance, adherence to speed limits, reaction to traffic lights, and overall reaction time after training using the PDS will not be significantly different from improvements observed after training using the high-fidelity driving simulator.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at P25-P50 for not_applicable parkinson-disease

Timeline
Completed

Started Aug 2019

Longer than P75 for not_applicable parkinson-disease

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 25, 2019

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 31, 2019

Completed
3 months until next milestone

Study Start

First participant enrolled

August 28, 2019

Completed
5.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2025

Completed
Last Updated

August 16, 2024

Status Verified

August 1, 2024

Enrollment Period

5.8 years

First QC Date

May 25, 2019

Last Update Submit

August 15, 2024

Conditions

Keywords

SimulationDriving Simulation

Outcome Measures

Primary Outcomes (3)

  • User-Friendliness

    User-Friendliness will be assessed using a User-Friendliness Survey which is a Likert scale. \[1-5 scale with 1 representing the lowest degree of user-friendliness and 5 representing the highest degree of user-friendliness\]

    Assessed at the End of visit 2, visit 3, and visit 4. These visits will take place over an average of one week.

  • Simulator Sickness

    Simulator Sickness and symptoms of Simulator Sickness will be assessed using questionnaire adapted from the 1993 Kennedy et al Simulator Sickness Questionnaire. \[This will be reported from a 0-228.14 scale with 0 representing the lowest possible degree of Simulator Sickness and 228.14 indicating the greatest possible degree of Simulator Sickness\]

    Assessed during visit 1, visit 2, visit 3, visit 4, and visit 5. These visits will take place over an average of one week.

  • Driving Performance

    Driving Performance will be assessment by a Driving rehabilitation specialist before and after each participant undergoes training. The participants will be tested on the high-fidelity driving simulator and the driving simulator provide objective measurements of lane position maintenance, adherence to speed limits, reaction to traffic lights, and overall reaction time.

    Assessed during visit 1, and visit 5. These visits will take place over an average of one week.

Study Arms (2)

Low-Fidelity PDS Training

EXPERIMENTAL

Individuals with stroke, PD, or MS

Device: Low-Fidelity PDS

High Fidelity Fixed-Base Simulator Training

ACTIVE COMPARATOR

Individuals with stroke, PD, or MS

Device: High Fidelity Fixed-Base Simulator

Interventions

The principal investigator recently developed a low cost ($10,000) low fidelity portable driving simulator (PDS) in the University of Kansas Laboratory for Advanced Rehabilitation Research in Simulation (LARRS) that measures 25.5" Wide, 32.5" High, and 25" Deep and requires only approximately 4 square feet of space. This intervention uses the PDS to retrain study participants and improve their driving related skills.

Also known as: Portable Driving Simulator
Low-Fidelity PDS Training

This intervention uses the large high-fidelity fixed-base driving simulator to retrain study participants and improve their driving related skills.

High Fidelity Fixed-Base Simulator Training

Eligibility Criteria

Age25 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of a first ever stroke, PD, or MS
  • Valid driver's licenses, ≥ 3 years driving experience,
  • Mini-mental State Examination score ≥24, and
  • Binocular acuity of at least 20/60 in compliance with state of Kansas driving laws

You may not qualify if:

  • \- Diagnosis of traumatic brain injury or any other neurological condition apart from stroke, PD, and MS.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Abiodun Akinwuntan

Kansas City, Kansas, 66160-8500, United States

RECRUITING

MeSH Terms

Conditions

Parkinson DiseaseMultiple SclerosisStroke

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative DiseasesDemyelinating Autoimmune Diseases, CNSAutoimmune Diseases of the Nervous SystemDemyelinating DiseasesAutoimmune DiseasesImmune System DiseasesCerebrovascular DisordersVascular DiseasesCardiovascular Diseases

Study Officials

  • Abiodun Akinwuntan, PhD, MPH MBA

    University of Kansas School of Health Professions

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Abiodun E Akinwuntan, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
The participant and the research assistant providing the training are not masked. The rest of the study conductors are masked regarding participant arm allocation.
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 25, 2019

First Posted

May 31, 2019

Study Start

August 28, 2019

Primary Completion

June 30, 2025

Study Completion

June 30, 2025

Last Updated

August 16, 2024

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will share

All data generated during the project will be entered into a secure REDCap database. This database will be housed on a secure network drive that is routinely backed-up to an offsite data storage location. Upon completion of the project, all data will be de-identified and available for other investigators at their request, in compliance with the NIH guidelines. The study team does not anticipate unique resources will be developed and thus are not providing a plan for resource sharing Sharing Model Organisms: Generation of new model organisms is not anticipated for this project. Genome-Wide Association Studies (GWAS): This project does not include a genome-wide association study.

Time Frame
The data will be available after the completion of the study.

Locations