Effects of Lead Exposure on Ferroptosis Pathway
Effects of Lead Exposure on Iron Metabolism and the Nrf2-dependent Ferroptosis Pathway
1 other identifier
observational
40
1 country
1
Brief Summary
The aim of this study was to investigate the effects of chronic lead exposure on iron metabolism and the Nrf2-dependent ferroptosis pathway in lead acid battery factory workers
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jul 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2023
CompletedFirst Submitted
Initial submission to the registry
July 11, 2023
CompletedFirst Posted
Study publicly available on registry
July 18, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 10, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
September 25, 2023
CompletedJuly 21, 2023
July 1, 2023
1 month
July 11, 2023
July 19, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Concentration of TNF-α level in peripheral blood
Biomarkers of the proinflammatory cytokines
From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 60 days
The relative mRNA expression rate of the Nrf2- dependent ferroptosis genes in peripheral blood
Biomarkers of the Nrf2- dependent ferroptosis
From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 60 days
The relative mRNA expression rate of the iron metabolism genes in peripheral blood
Biomarkers of the iron metabolism
From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 60 days
Study Arms (2)
The control group
The invited non-lead-exposed workers live in Yangzhou, Jiangsu, China
The lead exposure group
The invited chronic-lead exposed workers live in Yangzhou, Jiangsu, China
Interventions
The lead-acid battery factory workers will exposure to lead via Inhalation of lead particles, ingestion of lead-contaminated dust and water.
Eligibility Criteria
The control group will be selected from the invited who live in Yangzhou city via the website, email, and poster. The lead exposure group will be selected from the invited volunteers who live in Yangzhou with the assistance of the Center for Disease Control and Prevention of Yangzhou, the website, email, and poster.
You may qualify if:
- Aged over 18 years old
- Work for the lead acid battery factory more than 10 years
You may not qualify if:
- Neurological disorders
- Endocrine diseases
- Cancer
- Exposure to any chemical pollutant before
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Wenjing Zhao
Yangzhou, Jiangsu, 225001, China
Biospecimen
The enrolled participant's peripheral whole blood samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
July 11, 2023
First Posted
July 18, 2023
Study Start
July 1, 2023
Primary Completion
August 10, 2023
Study Completion
September 25, 2023
Last Updated
July 21, 2023
Record last verified: 2023-07