Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals
1 other identifier
interventional
12
1 country
1
Brief Summary
The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2022
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2022
CompletedFirst Submitted
Initial submission to the registry
July 3, 2023
CompletedFirst Posted
Study publicly available on registry
July 14, 2023
CompletedJuly 14, 2023
July 1, 2023
4 months
July 3, 2023
July 12, 2023
Conditions
Outcome Measures
Primary Outcomes (7)
Systolic blood pressure (mmHg) by sphygmomanometer
Measured from the brachial artery
24 hours
Diastolic blood pressure (mmHg) by sphygmomanometer
Measured from the brachial artery
24 hours
Mean arterial pressure (mmHg)
calculated (MAP = (SBP-DBP)/3 + DBP
24 hours
Heart rate (bpm)
measured using Physio Flow (non-invasive device)
24 hours
Stroke volume (ml)
measured using Physio Flow (non-invasive device)
24 hours
Cardiac output (l/min)
calculated: HR (bpm) x SV (ml)
24 hours
Total peripheral resistance (mmHg/l/min)
calculated: MAP (mmHg) / CO (l/min)
24 hours
Study Arms (2)
Randomized double blind grape seed extract design
ACTIVE COMPARATORGrape seed extract
Control
PLACEBO COMPARATORPlacebo (starch)
Interventions
Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.
Eligibility Criteria
You may qualify if:
- Healthy volunteers (SBP \< 120 mmHg, DBP \< 80 mmHg)
You may not qualify if:
- cardiovascular and/or pulmonary disease,
- musculoskeletal disorders
- medications that prevent the safe completion of the exercise protocol
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
California Baptist University
Riverside, California, 92504, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jong-Kyung Kim
California Baptist University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 3, 2023
First Posted
July 14, 2023
Study Start
May 1, 2022
Primary Completion
August 31, 2022
Study Completion
August 31, 2022
Last Updated
July 14, 2023
Record last verified: 2023-07