NCT05940272

Brief Summary

The purpose of this study is to develop and test a new communication training intervention called Hematolo-GIST to help oncologists communicate with patients about their lymphoma diagnosis and advance care planning.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
26mo left

Started Jul 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress57%
Jul 2023Jul 2028

First Submitted

Initial submission to the registry

July 3, 2023

Completed
Same day until next milestone

Study Start

First participant enrolled

July 3, 2023

Completed
8 days until next milestone

First Posted

Study publicly available on registry

July 11, 2023

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 3, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 3, 2028

Last Updated

October 9, 2025

Status Verified

October 1, 2025

Enrollment Period

5 years

First QC Date

July 3, 2023

Last Update Submit

October 8, 2025

Conditions

Keywords

oncologisthemotologic oncologistlymphomalarge cell lymphomalarge b-cell lymphomaDLBCLDiffuse Large B Cell LymphomaMediastinal B-Cell Diffuse Large Cell LymphomaHematolo-GIST23-164Memorial Sloan Kettering Cancer Center

Outcome Measures

Primary Outcomes (1)

  • Feasibility of the Hematolo-GIST intervention among hematologists and participants

    Feasbility is defined as ≥70% of screened eligible hematologists and participants enrolling in the study and ≥80% of hematologists learning the approach

    Up to 1 year

Study Arms (2)

Hematologists

EXPERIMENTAL

Hematologists will be recruited from the lymphoma clinics at MSK

Behavioral: Hematolo-GIST Training

Participants Patients

EXPERIMENTAL

Participant patients are being treated by a hematologic oncologist participating in this study

Behavioral: Participants Appointment

Interventions

Hematologist will participate in a group Hematolo-GIST training provided remotely via the study team.

Hematologists

Participants will meet with Hematolo-GIST trained hematologists. Participants will consent to having their appointment audio-recorded on password-protected devices or MSK approved secure platforms.

Participants Patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Providers
  • Currently a an MSK provider caring for patients with DLBCL (including DLBCL-transformed follicular lymphoma (TFL) and primary mediastinal B-cell lymphoma (PMBCL) which are histologically similar and treated as large-cell lymphoma)
  • Patients
  • Per medical record, is currently being treated by a provider who is participating in this study (for the purposes of this study, "treating provider" will be defined as any provider who provides care related to the patient's lymphoma diagnosis)
  • Per medical record, has a diagnosis of DLBCL including DLBCL-transformed follicular lymphoma (TFL) and primary mediastinal B-cell lymphoma (PMBCL) which are histologically similar and clinically treated as large-cell lymphoma
  • Per medical record, relapse/ refractory disease within 12 months of 4 cycles of first line therapy OR relapse after 2 cycles of later line therapy or or autologous stem cell transplant (ASCT)
  • Self-identify as Black and/or White
  • Per medical record, 18 years of age or older
  • Per self-report, fluent in English\*\*
  • Language verification: Prior to enrollment, patients will be asked the following two questions by a Clinical Research Coordinator (CRC) to verify English fluency necessary for participation in the study:
  • How well do you speak English? (must respond "very well" or "well" when given the choices of Very well, Well, Not well, Not at all, Don't know, or Refused)
  • What is your preferred language for healthcare? (must respond English)

You may not qualify if:

  • Providers
  • Per self-report, planning to leave the cancer center in the next 12 months
  • Patients
  • Cognitively impaired as demonstrated by (Blessed Orientation- Memory- Concentration (BOMC) score of ≥ 11
  • Per research staff judgment and/or self-report, too ill or weak to complete study procedures
  • Per medical record or self-report, receiving hospice care at the time of enrollment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Memorial Sloan Kettering Cancer Center (All protocol activities)

New York, New York, 10065, United States

RECRUITING

NEW YORK PRESBYTERIAN HOSPITAL (Data Collection Only)

New York, New York, 10065, United States

NOT YET RECRUITING

Related Links

MeSH Terms

Conditions

Lymphoma, B-CellLymphomaDendritic Cell Sarcoma, InterdigitatingLymphoma, Large B-Cell, Diffuse

Condition Hierarchy (Ancestors)

Lymphoma, Non-HodgkinNeoplasms by Histologic TypeNeoplasmsLymphoproliferative DisordersLymphatic DiseasesHemic and Lymphatic DiseasesImmunoproliferative DisordersImmune System DiseasesHistiocytic Disorders, MalignantHistiocytosis

Study Officials

  • Kelly McConnell, PhD

    Memorial Sloan Kettering Cancer Center

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Kelly McConnell, PhD

CONTACT

Revecca Saracino, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 3, 2023

First Posted

July 11, 2023

Study Start

July 3, 2023

Primary Completion (Estimated)

July 3, 2028

Study Completion (Estimated)

July 3, 2028

Last Updated

October 9, 2025

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will share

• Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.

Locations