Cardiac and Pulmonary Assessment in Egyptian Patients With Rheumatoid Arthritis

NCT05938244 | Unknown

• 1 other identifier: Cardiopulmonary RA
• Study Type: observational
• Target: 34
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine cardiac and pulmonary involvement in RA patients To assess the correlation between cardiopulmonary findings in RA patients with disease activity. To compare between diaphragmatic ultrasonography and PFT i.e. spirometry as a screening tool for restrictive pulmonary disorders. To assess correlation between anterior chest wall ultrasound and pulmonary function test in RA patients.

Conditions

Rheumatoid Arthritis

Keywords

cardiac pulmonary rheumatoid arthritis

Outcome Measures

Primary Outcomes (1)

• To determine cardiac and pulmonary involvement in RA patients

  By using spirometry, echocardiography

  1 year

Secondary Outcomes (3)

• To assess the correlation between cardiopulmonary findings in RA patients with disease activity

  1 year

• To compare between diaphragmatic ultrasonography and PFT i.e. spirometry as a screening tool for restrictive pulmonary disorders

  1 year

• To assess correlation between anterior chest wall ultrasound and pulmonary function test in RA patients

  1 year

Study Arms (2)

case/ diseased patients

ultra sound anterior chest wall echocardiogram pulmonary function test diaphragmatic ultra sound lipid profile Rheumatoid factor Anti-ccp

control/ normal population

ultra sound anterior chest wall echocardiogram pulmonary function test diaphragmatic ultra sound lipid profile Rheumatoid factor Anti-ccp

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

all Egyptian patients admitted to Assuit university hospitals with rheumatoid arthritis

You may qualify if:

• Any patient satisfying 2010 ACR/ EULAR RA classification criteria

You may not qualify if:

• Patients with definite diagnosis for any other systemic autoimmune disorders

Sponsors & Collaborators

• Assiut University: lead

Related Publications (10)

• Rodriguez-Henriquez P, Solano C, Pena A, Leon-Hernandez S, Hernandez-Diaz C, Gutierrez M, Pineda C. Sternoclavicular joint involvement in rheumatoid arthritis: clinical and ultrasound findings of a neglected joint. Arthritis Care Res (Hoboken). 2013 Jul;65(7):1177-82. doi: 10.1002/acr.21958.

  PMID: 23335586 BACKGROUND

• Hannawi SM, Hannawi H, Al Salmi I. Cardiovascular Risk in Rheumatoid Arthritis: Literature Review. Oman Med J. 2021 May 31;36(3):e262. doi: 10.5001/omj.2021.25. eCollection 2021 May.

  PMID: 34164156 BACKGROUND

• Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A. Rheumatoid arthritis: Extra-articular manifestations and comorbidities. Autoimmun Rev. 2021 Apr;20(4):102776. doi: 10.1016/j.autrev.2021.102776. Epub 2021 Feb 17.

  PMID: 33609792 BACKGROUND

• Choy E, Ganeshalingam K, Semb AG, Szekanecz Z, Nurmohamed M. Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment. Rheumatology (Oxford). 2014 Dec;53(12):2143-54. doi: 10.1093/rheumatology/keu224. Epub 2014 Jun 6.

  PMID: 24907149 BACKGROUND

• Tekeli̇ AH. Pulmonary and cardiac involvement in patients with rheumatoid arthritis and ankylosing spondylitis. Eur Res J. 2023 Jan 14;1-10.

  BACKGROUND

• Pinheiro FA, Souza DC, Sato EI. A Study of Multiple Causes of Death in Rheumatoid Arthritis. J Rheumatol. 2015 Dec;42(12):2221-8. doi: 10.3899/jrheum.150166. Epub 2015 Oct 15.

  PMID: 26472415 BACKGROUND

• Alunno A, Gerli R, Giacomelli R, Carubbi F. Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis. Biomed Res Int. 2017;2017:7915340. doi: 10.1155/2017/7915340. Epub 2017 Nov 7.

  PMID: 29238722 BACKGROUND

• Salaffi F, Carotti M, Di Carlo M, Tardella M, Giovagnoni A. High-resolution computed tomography of the lung in patients with rheumatoid arthritis: Prevalence of interstitial lung disease involvement and determinants of abnormalities. Medicine (Baltimore). 2019 Sep;98(38):e17088. doi: 10.1097/MD.0000000000017088.

  PMID: 31567944 BACKGROUND

• Kelly C, Iqbal K, Iman-Gutierrez L, Evans P, Manchegowda K. Lung involvement in inflammatory rheumatic diseases. Best Pract Res Clin Rheumatol. 2016 Oct;30(5):870-888. doi: 10.1016/j.berh.2016.10.004. Epub 2016 Nov 9.

  PMID: 27964793 BACKGROUND

• Mortada MA, Abdelrahman FI, Abdul-Sattar A, Mansour W. Relation between pulmonary function tests and ultrasonographic changes of asymptomatic anterior chest wall joints in rheumatoid arthritis patients. Egypt J Bronchol. 2022 Dec;16(1):8.

  BACKGROUND

MeSH Terms

Conditions

Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Sara F. Ahmed, Lecturer

  Assiut University

  STUDY CHAIR

• Manal M. Hassanien, Assistent prof.

  Assiut University

  STUDY CHAIR

• Samar H. Goma, Professor

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Yosra Y. Mahmoud

CONTACT

+201140408392; yoyomynmy@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: June 25, 2023
• First Posted: July 10, 2023
• Study Start: August 1, 2023
• Primary Completion: December 1, 2023
• Study Completion: June 1, 2024
• Last Updated: July 10, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share