Delta Waves and Cognitive Recovery

NCT05924737 | Completed

• 2 other identifiers: 2023_RECOPS2023-A01221-44
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

In a laboratory protocol in healthy adults, exposed to a prolonged period of wakefulness with a restricted opportunity for sleep (40h of wakefulness / 3h of sleep / 21h of wakefulness), we hypothesize that the relative increase in spectral power of Delta waves \[ 1 - 4 Hz\] in NREM in the frontal territory, identified as a potential marker of the restorative function of sleep, during a night of sleep with limited recovery (3 h of time in bed) after sleep deprivation (40 h of continuous wakefulness), will be less important in subjects with poor recovery in terms of cognitive performance than in those with good recovery.

Conditions

Sleep Deprivation; Cognitive Impairment

Keywords

recovery; sleep

Outcome Measures

Primary Outcomes (1)

• Delta power

  EEG Delta power in Hz

  One night

Secondary Outcomes (1)

• Cognitive performance

  2 days

Study Arms (1)

Sleep

EXPERIMENTAL

Sleep deprivation

Other: Sleep deprivatin; Other: Sleep recovery

Interventions

Sleep deprivatin OTHER

40 hours of continuous awakening

Sleep

Sleep recovery OTHER

sleep recovery after 40 hours of continuous awakening

Sleep

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy volunteer man or woman
• Between 18 and 45 years of age
• Having given written consent after having been informed of the terms of the study and the objectives of the genetic analysis performed

You may not qualify if:

• Current medical treatment
• Chronic medical pathology, (psychol, cardiovascular or respiratory, sleep disorders)
• Pregnancy
• Sleep disorder
• Extreme chronotype
• Excessive daytime sleepiness
• Suspicion of anxiety or depressive disorder
• Estimated caffeine consumption \> 200mg/day
• Not covered by a health insurance

Sponsors & Collaborators

• Institut de Recherche Biomedicale des Armees: lead
• Hotel Dieu de France Hospital: collaborator
• University of Paris 5 - Rene Descartes: collaborator

Study Sites (1)

Institut de recherche biomédical des armées

Brétigny-sur-Orge, 91220, France

Location

MeSH Terms

Conditions

Sleep Deprivation; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Cognition Disorders; Neurocognitive Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Model Details: Sleep deprivation followed by a short and a long recovery nigjht

Study Record Dates

• First Submitted: June 12, 2023
• First Posted: June 29, 2023
• Study Start: October 1, 2023
• Primary Completion: March 30, 2024
• Study Completion: April 30, 2024
• Last Updated: June 24, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)