Role of Neuronal Guidance Proteins as Diagnostic Markers for Acute Kidney Injury (AKI)

NCT05924269 | Not Yet Recruiting

• 1 other identifier: NEUKID
• Study Type: observational
• Target: 600
• Locations: 0 countries
• Sites: N/A

Brief Summary

Acute kidney failure remains one of the most challenging entities to diagnose in clinical medicine, especially in the field of intensive care. The diagnosis of acute kidney injury is based solely on urine output and serum creatinine, both of which could also be influenced by other factors. A more sensitive and faster diagnostic option would not only be desirable but of utmost clinical importance. Therefore, the investigators aim to identify Neuronal Guidance Proteins (NGPs) as potential biomarkers for the identification and early detection of AKI with this investigation. This investigation aims to identify the possibility of diagnosing acute kidney injury, the subsequent validation of a potential biomarker will then have to take place in a multicenter study approach: Data in preclinical mouse models suggest that SEMA7A as one of the NGPs could be valuable as a biomarker, the study now aims to attempt a preliminary survey in humans and measure various NGPs.

Conditions

Acute Kidney Injury

Keywords

Neuronal Guidance Protein; Acute Kidney Injury

Outcome Measures

Primary Outcomes (1)

• AKI

  Development of AKI after cardiac surgery

  1-7 days

Secondary Outcomes (1)

• NGP

  1-7 days

Study Arms (1)

Cardiac Surgery

Patients undergoing cardiac surgery

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients undergoing elective cardiac surgery followed by postoperative surveillance in the intensive care unit

You may qualify if:

• Patients undergoing cardiac surgery
• written consent

You may not qualify if:

• no written consent possible
• Polytrauma, severe burns
• Immunosuppression
• Pregnancy
• Diagnosis of Hepatitis B, Hepatitis C, and/or HIV
• Sepsis
• Pre-existing kidney damage

Sponsors & Collaborators

• University Hospital Tuebingen: lead

Biospecimen

Retention: SAMPLES WITH DNA

Blood, Urine

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Andreas Körner, MD

  University Clinic of Tuebingen

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Andreas Körner, MD

CONTACT

+497071-29 61783; andreas.koerner@med.uni-tuebingen.de

Michael Koeppen, MD

CONTACT

+497071-29 86935; michael.koeppen@med.uni-tuebingen.de

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 20, 2023
• First Posted: June 29, 2023
• Study Start: August 1, 2023
• Primary Completion: July 1, 2026
• Study Completion: July 1, 2026
• Last Updated: July 5, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share