Multifactorial Approach to Dementia, Multicentric Study

NCT05923307 | Unknown DMC

• 1 other identifier: 01569
• Study Type: observational
• Target: 450
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to assess the role of narcisistic personality disorder and life stressful events in conversion rate to dementia, using a three tier approach along three research lines employing subjects with dementia in retrospective assessment, and normal subjects no yet developing demetia in prospective follow up. The main question\[s\] it aims to answer are:

• narcisistic personality disorder as risk factor for conversion to dementia
• life stressful events as risk factor for conversion to dementia Participants will be assessed with a complete neurocognitive battery, brain images studies, laboratory analysis, and sociodemographic profile, including depression and comorbidities.

Conditions

Dementia of Alzheimer Type; Dementia Frontotemporal; Narcissistic Personality Disorder; Depression; Personality Change

Outcome Measures

Primary Outcomes (1)

• new onset of dementia during the follow-up period

  dementia diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders V, considered affected by dementia when agreement on this diagnosis was reached between a psychologist and a geriatrician. If the physicians failed to agree, the diagnosis had to be confirmed by a second geriatrician.

  1 year

Secondary Outcomes (1)

• univariate proportional hazard ratios for narcissistic personality as risk factor, adjusted for age and sex

  1 year

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

individuals eligible to participate were diagnosed with dementia, or had inconclusive results living at the community or residential institutions invited to attend a follow-up, cognitively healthy or minimally impaired, or had mild cognitive impairment (MCI), or dementia

You may qualify if:

• research line 3
• healthy subjects over 50 years of age.
• diagnosis of dementia should be made according to DSM V criteria.
• Diagnoses made by operationalised criteria for dementia

You may not qualify if:

• Participants excluded if declined participation, died or withdrew from the study
• unable to perform the assessments due to other co-morbid conditions
• were too visually impaired to complete cognitive assessments.
• putative narcisistic personality disorder
• no age limit

Sponsors & Collaborators

• Daniel Serrani Azcurra: lead
• Zarebski Graciela, Kabanchik Alicia, Marconi Araceli: collaborator

Study Sites (1)

universidad Atlantida

Buenos Aires, Outside U.S. and Canada, 1405, Argentina

RECRUITING

Related Publications (5)

• Fiest KM, Jette N, Roberts JI, Maxwell CJ, Smith EE, Black SE, Blaikie L, Cohen A, Day L, Holroyd-Leduc J, Kirk A, Pearson D, Pringsheim T, Venegas-Torres A, Hogan DB. The Prevalence and Incidence of Dementia: a Systematic Review and Meta-analysis. Can J Neurol Sci. 2016 Apr;43 Suppl 1:S3-S50. doi: 10.1017/cjn.2016.18.

  PMID: 27307127 RESULT

• Ganguli M, Dodge HH, Chen P, Belle S, DeKosky ST. Ten-year incidence of dementia in a rural elderly US community population: the MoVIES Project. Neurology. 2000 Mar 14;54(5):1109-16. doi: 10.1212/wnl.54.5.1109.

  PMID: 10720283 RESULT

• serrani daniel Narcissism Vulnerability as Risk Factor for Alzheimer´s Disease- A Prospective Study Austin J Clin Neurol 2015;2(7): 1057.

  RESULT

• Chatterjee A, Strauss ME, Smyth KA, Whitehouse PJ. Personality changes in Alzheimer's disease. Arch Neurol. 1992 May;49(5):486-91. doi: 10.1001/archneur.1992.00530290070014.

  PMID: 1580810 RESULT

• Wilson RS, Schneider JA, Arnold SE, Bienias JL, Bennett DA. Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment. Arch Gen Psychiatry. 2007 Oct;64(10):1204-12. doi: 10.1001/archpsyc.64.10.1204.

  PMID: 17909133 RESULT

MeSH Terms

Conditions

Pick Disease of the Brain; Narcissistic Personality Disorder; Depression

Condition Hierarchy (Ancestors)

Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Personality Disorders; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal researcher

Study Record Dates

• First Submitted: June 19, 2023
• First Posted: June 28, 2023
• Study Start: May 20, 2023
• Primary Completion: April 20, 2024
• Study Completion: September 20, 2024
• Last Updated: July 6, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share

Locations

AR (1)