NCT05918770

Brief Summary

The goal of this randomized study is to assess the impact on self-perceived quality of life (QoL) of systematic screening and early treatment of aftereffects in patients with gynaecological cancers. The main question it aims to answer is if systematic screening with validated questionaries (see in detailed description), diagnosis and early treatment of lower-limb lymphoedema, anxiety-depression, sexual dysfunction and sarcopenia-malnutrition all have a positive impact on the self-perceived QoL by gynaecological cancer patients. Participants will access the screening questionnaires and QoL questionaries on a free online app on their mobile devices. In the experimental group, in case of positive screening, patients will be referred to specialised care to early treatment of the aftereffects. Researchers will compare this group with standard usual care (opportunistic treatment) to see if systematic screening and early treatment lead to a better QoL.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
168

participants targeted

Target at P75+ for not_applicable quality-of-life

Timeline
4mo left

Started Sep 2023

Longer than P75 for not_applicable quality-of-life

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress89%
Sep 2023Sep 2026

First Submitted

Initial submission to the registry

June 5, 2023

Completed
21 days until next milestone

First Posted

Study publicly available on registry

June 26, 2023

Completed
2 months until next milestone

Study Start

First participant enrolled

September 1, 2023

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Last Updated

June 26, 2023

Status Verified

June 1, 2023

Enrollment Period

3 years

First QC Date

June 5, 2023

Last Update Submit

June 23, 2023

Conditions

Keywords

quality of lifeGynaecological cancer

Outcome Measures

Primary Outcomes (1)

  • Quality-of-life questionaries score

    Unit on QLQ-C30 Quality-of-life scale

    up to 20 months

Secondary Outcomes (3)

  • Quality-of-life questionaries score related to endometrial cancer

    up to 20 months

  • Quality-of-life questionaries score related to cervical cancer

    up to 20 months

  • Quality-of-life questionaries score related to ovarian cancer

    up to 20 months

Study Arms (2)

experimental group

EXPERIMENTAL

in case of positive screening, the online app will alert and the patient will be referred to the corresponding area for diagnosis and early treatment (Rehabilitation, Psycho-oncology, Sexual health and Nutrition)

Diagnostic Test: systematic screening and early treatment

control group

NO INTERVENTION

will follow the standard usual care guidelines at the centre where patients will be opportunistically referred to specialised care

Interventions

in case of positive screening, the online app will alert and the patient will be referred to the corresponding area for diagnosis and early treatment (Rehabilitation, Psycho-oncology, Sexual health and Nutrition

experimental group

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Women aged ≥18 diagnosed with ovarian, tubal and primary peritoneal, cervical and endometrial cancer who are candidates for surgery during the study period.

You may not qualify if:

  • Patients unable to complete by themselves the screening questionnaires included.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Gil-Ibanez B, Tejerizo-Garcia A, Oliver MR, Madariaga A, Maiz Jimenez M, Gil Garcia A, Lopez-Gonzalez G. Side effects screening and early intervention to impact in quality of life of patients with gynecological cancers (HALIS study). Int J Gynecol Cancer. 2023 Oct 2;33(10):1645-1648. doi: 10.1136/ijgc-2023-004802.

MeSH Terms

Conditions

LymphedemaSexual Dysfunction, Physiological

Condition Hierarchy (Ancestors)

Lymphatic DiseasesHemic and Lymphatic DiseasesGenital DiseasesUrogenital Diseases

Central Study Contacts

Blanca Gil-Ibañez, MD, PhD

CONTACT

Gregorio Lopez, MD,PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigador, MD, PhD

Study Record Dates

First Submitted

June 5, 2023

First Posted

June 26, 2023

Study Start

September 1, 2023

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

June 26, 2023

Record last verified: 2023-06