Human Hydration Status Monitoring

NCT01124903 | Completed

• 1 other identifier: H08-12
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

The sports medicine literature provides a consensus on what threshold values constitute euhydration (normal body water) using a variety of hydration assessment markers (e.g., blood, urine). The investigators add to this literature by providing decision levels for multiple body fluids which can be used as starting points for diagnosing and treating dehydration. At present, plasma osmolality (Posm) provides the best potential measure for static dehydration assessment (spot measure), while dynamic dehydration assessment (serial monitoring) is best accomplished using change values for Posm, urine specific gravity, or body mass (weight). These findings should be considered useful for clinical, military, and sports medicine communities.

Conditions

Dehydration

Keywords

dehydration; hypohydration; diagnostic accuracy; biological variation; hydration assessment; body mass; osmolality; plasma; saliva; urine

Outcome Measures

Primary Outcomes (1)

• Evidence of clinical dehydration

  Dehydration was carefully imposed in healthy human subjects. The diagnostic usefulness of multiple classic and novel dehydration assessment measures was made.

  24 hours

Study Arms (1)

Dehydration

EXPERIMENTAL

Multiple measures of hydration status were made when subjects were normally hydrated (euhydrated) and when dehydrated. The diagnostic usefulness of the measures was determined.

Procedure: Dehydration

Interventions

Dehydration PROCEDURE

Subjects were dehydrated by 2 - 7% of body mass over 3-5 hours using exercise-heat stress and fluid restriction.

Also known as: Hypohydration

Dehydration

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• You are a member of the U.S. Army between 18-39 years of age
• You have passed the APFT within the previous 12 months
• You have completed and passed a recent medical physical exam
• You are willing to discuss with OMSO and the Principle Investigator (PI) all medications and supplements you are taking and you are willing to stop taking any supplements not approved by OMSO and the PI.

You may not qualify if:

• You have any physical problems that would make exercise difficult
• You have ever had a heat injury or have a history of having trouble in the heat
• You have an allergy to sulfa drugs
• You have been treated for dry eyes
• You are pregnant, planning on becoming pregnant during the study, or are presently lactating

Sponsors & Collaborators

• United States Army Research Institute of Environmental Medicine: lead
• ChromoLogic, LLC: collaborator
• Intelligent Automation, Inc.: collaborator
• Gaia Medical Institute: collaborator

Study Sites (1)

USARIEM

Natick, Massachusetts, 01760-5007, United States

Location

MeSH Terms

Conditions

Dehydration

Interventions

Organism Hydration Status

Condition Hierarchy (Ancestors)

Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physiological Phenomena

Study Officials

• Samuel N Cheuvront, PhD

  United States Army Research Institute of Environmental Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: SINGLE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED
• Responsible Party: SPONSOR

Model Details: single-sample pre-post design

Study Record Dates

• First Submitted: May 14, 2010
• First Posted: May 17, 2010
• Study Start: January 1, 2009
• Primary Completion: February 1, 2011
• Study Completion: March 1, 2011
• Last Updated: April 22, 2020

Record last verified: 2020-04

Locations

US (1)