Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

You may not qualify if:

• A score on the Columbia Suicide Severity Rating Scale in the "intent" or "intent with plan" categories or judged by Dr. Krystal or Dr. Driesen to be at serious risk for suicide.
• Neurological disorder excluding migraine headaches or more than mild head injury. Individuals with migraines will not complete any ketamine infusion visits within 24 hours of a migraine. More than mild head injury is indicated by the presence of any of the following:
• More than half hour unconsciousness after trauma
• More than one hour post-traumatic amnesia
• Concussive symptoms such as headache, memory problems, nausea/vomiting, irritability, ringing in the ears, dizziness, balance problems, difficulty concentrating or visual disturbances lasting more than one week after injury.
• Concussive symptoms as defined above in the first week after injury causing more than one day impairment in typical duties.
• Current therapeutic treatment with ketamine
• Current treatment with topiramate, memantine, or barbiturates within two weeks of randomization
• Daytime use of benzodiazepines
• Current treatment with monoamine oxidase inhibitors within 4 weeks of randomization
• Treatment with a vagal nerve stimulator, ECT or deep brain stimulation within two weeks of randomization
• Psychosis other than psychotic experiences congruent with depressed mood during a period of depression
• Insulin-dependent diabetes or non-insulin dependent diabetes that is poorly controlled
• Other major medical disorder unless cleared by a study physician
• History of violence unless cleared by Dr. Driesen or Dr. Krystal because of extenuating circumstances. For example, an individual whose violent behavior was always coupled with substance abuse and had obtained stable sobriety with no violent incidents or an individual who had received successful pharmacotherapy for impulse control difficulties may be included.
• +16 more criteria