Depressive Disorder, Major
352
32
38
236
Key Insights
Highlights
Success Rate
90% trial completion (above average)
Published Results
104 trials with published results (30%)
Research Maturity
236 completed trials (67% of total)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 17/100
7.7%
27 terminated out of 352 trials
89.7%
+3.2% vs benchmark
28%
100 trials in Phase 3/4
44%
104 of 236 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 236 completed trials
Clinical Trials (352)
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
Psilocybin for Major Depressive Disorder (MDD)
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Individualized Functional Connectivity Targeting in aiTBS for Depression
A Study to Evaluate Sleep Electroencephalogram (EEG) Features (Brain Activity While Sleeping) in Participants With Major Depressive Disorder (MDD)
Brain Functional Connectivity Mechanism of Cognitive Flexibility Impairment and rTMS Intervention in Major Depressive Disorder
Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
Student Precarity and Psychiatry
A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure
A Study to Test Different Doses of BI 1569912 in People With Depression
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation
Personalized Sertraline Dosing in Patients With Depression
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder
Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients