Depressive Disorder, Major
351
33
39
234
Key Insights
Highlights
Success Rate
90% trial completion (above average)
Published Results
99 trials with published results (28%)
Research Maturity
234 completed trials (67% of total)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 17/100
7.7%
27 terminated out of 351 trials
89.7%
+3.1% vs benchmark
28%
100 trials in Phase 3/4
42%
99 of 234 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 234 completed trials
Clinical Trials (351)
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder
Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients
Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia
Cognitive Fitness for Depression in Older Adults
NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits
bWell-D Pilot Randomized Controlled Trial
Zelquistinel in the Treatment of Major Depressive Disorder
Psilocybin for Major Depressive Disorder (MDD)
Neuroimaging Study for Decoding Emotional States and Identifying Neural Circuits to Disengage From Negative Thinking
A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)
MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients
A Study of Psilocybin for Major Depressive Disorder (MDD)
Prospective Assessment of Cost-effectiveness and Side-effects of Depressive Patients Treated With ECT or TCA
Clinical Efficacy, Safety, and Applicability of Home-based Bright Light Therapy in Outpatient Adolescents With Major Depressive Disorder
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)
Trial of Transcranial Photobiomodulation for Depression With PET and EEG Outcomes
A Study to Evaluate Sleep Electroencephalogram (EEG) Features (Brain Activity While Sleeping) in Participants With Major Depressive Disorder (MDD)