Early Predictors for the Short Term Native Liver Survival in Patients With Biliary Atresia After Kasai Procedure

NCT05909033 | Unknown

• 1 other identifier: NanjingCH20230601
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Many factors have been proven that may affect NLS in BA patients after KP;however,the early predictors for NLS were not be finally detected.This study was designed to evaluate and identify the preoperative and early postoperative factors associated with NLS for early prediction in BA patients after KP.

Conditions

Biliary Atresia

Keywords

biliary Atresia; Kasai procedure; early predictor; native liver survival

Outcome Measures

Primary Outcomes (1)

• NLS rate

  native liver survival rate

  through study completion, an average of 3 years

Secondary Outcomes (3)

• age at KP

  through study completion, an average of 3 years

• PC

  through study completion, an average of 3 years

• JC

  through study completion, an average of 3 years

Interventions

Kasai procedure PROCEDURE

All KPs were performed by a medical team. This technique involved creation of a 35-40 cm Roux loop to facilitate biliary drainage. After dissection of the hepatic vasculature at the hilum and excision of the hilar plate, hepaticojejunostomy was performed as an anastomosis extending from the bifurcation of the right hepatic artery into anterior and posterior branches to the Rex confluence of the left portal vein with the obliterated umbilical vein.

Eligibility Criteria

• Age: 6 Months - 6 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

patients with Biliary atreisa and were performed with kasai procedures

You may qualify if:

• Biliary Atresia(BA) patients performed with Kasai Procedure patients completed the follow-up\>6 months

You may not qualify if:

• BA patients without KP patients lost of follow-up BA patients with other severe complications lead to death

Sponsors & Collaborators

• Weibing Tang: lead

Study Sites (1)

Children's Hospital of Nanjing Medical University

Nanjing, 210008, China

RECRUITING

Related Publications (1)

• Lu C, Xie H, Zhu Z, Ding Z, Geng Q, Tang W. A convenient nomogram for predicting early death or liver transplantation after the Kasai procedure in patients with biliary atresia. Langenbecks Arch Surg. 2024 Jan 8;409(1):30. doi: 10.1007/s00423-023-03216-5.

  PMID: 38189999 DERIVED

MeSH Terms

Conditions

Biliary Atresia

Interventions

Portoenterostomy, Hepatic

Condition Hierarchy (Ancestors)

Bile Duct Diseases; Biliary Tract Diseases; Digestive System Diseases; Digestive System Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Anastomosis, Surgical; Surgical Procedures, Operative; Biliary Tract Surgical Procedures; Digestive System Surgical Procedures

Study Officials

• Weibing Tang, Dr

  Children's Hospital of Nanjing Medical University

  STUDY DIRECTOR

• Weibing Tang, Dr

  Children's Hospital of Nanjing Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Changgui Lu, Dr

CONTACT

13770848448; luchanggui1984@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: June 8, 2023
• First Posted: June 18, 2023
• Study Start: May 20, 2017
• Primary Completion: July 1, 2023
• Study Completion: July 1, 2023
• Last Updated: June 18, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)