The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron Hyperexcitability
MnHyperex
MnHyperex
Sponsor study identifier
interventional
110
1 country
1
Study Start
October 1, 2023
Actual (reported)Primary Completion
December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
In the present project, the investigators aim at proposing innovative ways of investigating spinal motoneuron hyperexcitability to counteract the associated impairments by using wide pulse high frequency neuromuscular electrical stimulation (WPHF NMES) in various populations. The investigators will use WPHF NMES contractions as a model to gain insights into the mechanisms underlying muscle cramps, restless legs syndrome or stroke-induced spasticity as there is evidence that they share common underlying mechanisms. The investigators will then use WPHF NMES as a training modality to improve plantar flexor neuromuscular function in stroke patients by taking advantage of their motoneuronal hyperexcitability.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 16, 2023
Actual (reported)June 18, 2023
Actual (reported)October 1, 2023
Actual (reported)December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change in maximal voluntary contraction force
Change from baseline maximal voluntary contraction force after the six-week training period in stroke patients
through study completion, an average of 8 weeks
Change in NMES-evoked force
Change from baseline NMES-evoked force after the six-week training period
through study completion, an average of 8 weeks
NMES-evoked force
Comparison of NMES-evoked force in plantar flexor muscles between patients (prone to cramps or restless legs) and healthy volunteers
through study completion, an average of 2 weeks
Participants in this group will take part in a 6-week WPHF NMES training period and plantar flexor neuromuscular function will be assessed before and after training.
Participants in this group will keep their daily life activities for 6 weeks and plantar flexor neuromuscular function will be assessed before and after training.
Plantar flexors will be stimulated with wide pulse high frequency neuromuscular electrical stimulation 3 times a week for 6 weeks
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Bâtiment Synathlon, quartier UNIL-Centre
Lausanne, 1015, Switzerland
First Submitted
May 16, 2023
First Posted
June 18, 2023
Study Start
October 1, 2023
Actual (reported)Change in estimates of persistent inward current (Delta F assessed with high-density surface electromyography and/ or the torque measured during vibration after the last bout of NMES)
Change from baseline estimates of persistent inward current after the six-week training period in stroke patients
through study completion, an average of 8 weeks
Estimates of persistent inward current (Delta F assessed with high-density surface electromyography and/ or the torque measured during vibration after the last bout of NMES)
comparison of estimates of persistent inward current strength in plantar flexor muscles between patients (prone to cramps or restless legs) and healthy volunteers
through study completion, an average of 8 weeks
Change in voluntary activation level and contractile properties of the plantar flexor muscles
through study completion, an average of 8 weeks
voluntary activation level and contractile properties of the plantar flexor muscles
through study completion, an average of 2 weeks
change in spasticity at the ankle joint level for stroke patients
through study completion, an average of 8 weeks
10-m walking test (s)
through study completion, an average of 8 weeks
6-min walking test (m)
through study completion, an average of 8 weeks
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Primary Completion
December 31, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 31, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
November 28, 2023
Record last verified: 2023-11
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Source: ClinicalTrials.gov.
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