NCT05895695

Brief Summary

The aim of this study was to compare the outcome of levator muscle resection with plication in mild to moderate congenital unilateral blepharoptosis.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 11, 2023

Completed
28 days until next milestone

First Posted

Study publicly available on registry

June 8, 2023

Completed
23 days until next milestone

Study Start

First participant enrolled

July 1, 2023

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2024

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2024

Completed
Last Updated

June 8, 2023

Status Verified

June 1, 2023

Enrollment Period

6 months

First QC Date

May 11, 2023

Last Update Submit

June 6, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Comparison of outcome of levator muscle resection and plication in mild to moderate congenital ptosis

    Comparison of surgical efficacy of levator muscle resection and plication regarding lid height as measured by MRD 1

    6 months

Study Arms (2)

1

ACTIVE COMPARATOR

evaluation of levator muscle resection on congenital ptosis

Procedure: levator muscle resection

2

ACTIVE COMPARATOR

evaluation of levator muscle plication on congenital ptosis

Procedure: levator muscle plication

Interventions

resection of levator muscle in congenital unilateral ptosis

1

plication of levator muscle in congenital unilateral ptosis

2

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • mild to moderate simple unilateral congenital ptosis with good to fair levator function

You may not qualify if:

  • severe ptosis
  • poor levator function
  • poor Bell's phenomenon
  • lagophthalmos
  • diminished corneal sensation
  • completed congenital or acquired ptosis
  • history of previous lid surgery

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sohag University Hospital

Sohag, Egypt

Location

Related Publications (4)

  • SooHoo JR, Davies BW, Allard FD, Durairaj VD. Congenital ptosis. Surv Ophthalmol. 2014 Sep-Oct;59(5):483-92. doi: 10.1016/j.survophthal.2014.01.005. Epub 2014 Feb 5.

    PMID: 24657037BACKGROUND
  • Nemet AY. Accuracy of Marginal Reflex Distance Measurements in Eyelid Surgery. J Craniofac Surg. 2015 Oct;26(7):e569-71. doi: 10.1097/SCS.0000000000001304.

    PMID: 26468822BACKGROUND
  • Hwang K. Surgical anatomy of the upper eyelid relating to upper blepharoplasty or blepharoptosis surgery. Anat Cell Biol. 2013 Jun;46(2):93-100. doi: 10.5115/acb.2013.46.2.93. Epub 2013 Jun 30.

    PMID: 23869256BACKGROUND
  • Baldwin HC, Manners RM. Congenital blepharoptosis: a literature review of the histology of levator palpebrae superioris muscle. Ophthalmic Plast Reconstr Surg. 2002 Jul;18(4):301-7. doi: 10.1097/01.IOP.0000021973.72318.07.

    PMID: 12142765BACKGROUND

Central Study Contacts

Maggi h Shaker, MBBCH

CONTACT

Islam a Aboellil, lecturer

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
resident ophthalmology department el helal hospital

Study Record Dates

First Submitted

May 11, 2023

First Posted

June 8, 2023

Study Start

July 1, 2023

Primary Completion

January 1, 2024

Study Completion

February 1, 2024

Last Updated

June 8, 2023

Record last verified: 2023-06

Locations