Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises Patient With Hemophilia
1 other identifier
interventional
46
1 country
1
Brief Summary
Hemophilia is a bleeding disorder caused by a deficiency of clotting factors in the blood. Muscle and joint bleeding are frequently observed in patients with hemophilia. Lower extremity bleeding can adversely affect balance, gait, and proprioception. The goal of this study; To compare the effectiveness of closed kinetic chain exercises and proprioceptive exercises on balance, proprioception and gait parameters in adolescent and young hemophilic individuals with lower extremity joint involvement. The main question it aims to answer is: Are the effects of closed kinetic chain exercises and proprioceptive exercises different on balance and walking in hemophilic individuals?
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Nov 2023
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 5, 2023
CompletedFirst Posted
Study publicly available on registry
May 30, 2023
CompletedStudy Start
First participant enrolled
November 15, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 30, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2025
CompletedJune 25, 2025
June 1, 2025
5 months
May 5, 2023
June 20, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Medio-lateral and Anterior-posterior stability index
Represents fluctuations from the horizontal around the mediolateral axis. Mediolateral sway and anterior-posterior stability will record in the double-leg stance for 20 seconds with Biodex Balance System. The feet are placed in a comfortable position for patients, and the center of gravity was recorded in the system to begin the test. Each test will repeat 3 times. A higher sway index indicates a decrease in postural stability.
12 weeks
walking speed
A 10-meter walking test will be used to evaluate walking.
12 weeks
Hemophilia joint health score
The HJHS is derived from a physical examination of the index joints by a health care professional who should have training and expertise in the conduct of a detailed musculoskeletal (MSK) examination. It is a measure of joint health and sits within the World . The current HJHS version 2.1 comprises an assessment of specific features, or items, of the six index joints and an assessment of global gait. For each of the six joints, the following items are scored: swelling (scored 0-3), duration of swelling (0-1), muscle atrophy (0-2), crepitus on motion (0-2), flexion loss (0-3), extension loss (0-3), joint pain (0-2), and strength (0-4). The maximum score for an individual index joint is 20. Gait is scored 0 to 4. The maximum HJHS total score is 124, with a higher score indicating worse joint health.
12 weeks
Secondary Outcomes (3)
Single leg stance test
12 weeks
Proprioception
12 weeks
2-dimensional video-based gait kinematic analysis
12 weeks
Study Arms (3)
Closed Chain Exercise Group
EXPERIMENTALClosed kinetic chain exercises will be given under the supervision of a physiotherapist, 2 sessions a week for 12 weeks.
Proprioceptive Exercise Group
EXPERIMENTALProprioceptive exercises will be given under the supervision of a physiotherapist, 2 sessions a week for 12 weeks.
Control Group
NO INTERVENTIONNo intervention will be applied.
Interventions
Eligibility Criteria
You may qualify if:
- Having been diagnosed with Hemophilia A and Hemophilia B
- Having a blood factor level below 5%,
- Between 13-25 years old
- History of bleeding to the lower extremity and target joint
- Total lower extremity Hemophilia joint health score ≥3
- Using prophylaxis
You may not qualify if:
- Having undergone lower extremity surgery in the last 6 months
- Having a Body Mass Index over 30 kg/m2
- Have an inhibitor
- Using a walking aid
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
İstanbul University-Cerrahpaşa
Istanbul, Turkey (Türkiye)
Related Publications (2)
Tat NM, Tat AM, Oner AF, Karaman K, Kaplan S, Can F. Static postural balance evaluation and an investigation of the relationship with joint health in children with severe haemophilia: a controlled cross-sectional study. Haemophilia. 2021 Mar;27(2):e245-e252. doi: 10.1111/hae.14240. Epub 2021 Jan 24.
PMID: 33486846BACKGROUNDPoyraz Isleyen T, Tarakci E, Leblebici G, Yeldan I, Zulfikar B. Comparison of Efficiency of Closed Kinetic Chain Exercises Versus Proprioceptive Exercises in Improving Balance and Gait in People With Hemophilia: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2025 Apr 24;14:e66770. doi: 10.2196/66770.
PMID: 40273449DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Lecturer
Study Record Dates
First Submitted
May 5, 2023
First Posted
May 30, 2023
Study Start
November 15, 2023
Primary Completion
March 30, 2024
Study Completion
June 1, 2025
Last Updated
June 25, 2025
Record last verified: 2025-06
Data Sharing
- IPD Sharing
- Will not share