Kuwait Heart Foundation Registry of Acute Coronary Events

NCT05857735 | Completed

• 1 other identifier: KHF1
• Study Type: observational
• Target: 10,812
• Locations: 1 country
• Sites: 1

Brief Summary

Acute coronary syndrome (ACS) is the most common presentation of Coronary Artery Disease (CAD). It causes significant morbidity and mortality. The Gulf Registry of Acute Coronary Events (Gulf RACE) was conducted in 2007 and filled a wide gap in our understanding of ACS and its management in Kuwait and the Arabian Gulf region. However, the management of ACS has undergone tremendous advances over the last two decades involving pharmacotherapy and device therapy. Practice guidelines have also changed over the last decade. For example, in 2007, there was no catheterization laboratory in any of the general hospitals in Kuwait, primary percutaneous coronary intervention (PCI) was not being practiced, and the rate of in-hospital cardiac catheterization for all ACS patients was very low at around 10%. Currently, of the eight general hospitals in Kuwait, six have catheterization laboratories and five of the six serve as primary PCI centers. There is no contemporary ACS registry in Kuwait, studying its incidence, management, and influence of current changes in clinical practice on patients' outcomes. This multicentre disease-based, country-wide registry is guided by the American Heart Association policy statement for expanding the applications of existing and future clinical registries and the User's Guide published by the Agency for Health care Research and Quality guidance.

Conditions

ACS

Keywords

Mortality; Inhospital MACE; 30-day MACE

Outcome Measures

Primary Outcomes (2)

• Mortality

  To measure the adverse outcome of in-hospital mortality in ACS patients in Kuwait.

  through study completion, an average of 6 months

• Major Adverse Cardiac Events (MACE)

  To measure the in-hospital adverse outcomes like myocardial infarction (MI), cerebrovascular accident (CVA), bleeding, cardiogenic shock, heart failure and others in ACS patients in Kuwait.

  through study completion, an average of 6 months

Secondary Outcomes (6)

• Mortality

  30 days from discharge

• Major Adverse Cardiac Events (MACE)

  30 days from discharge

• Rehospitalization

  within 30 days from discharge

• Revascularization

  within 30 days from discharge

• Lipid level control

  At 6 months from ACS event

Study Arms (1)

ACS patients

Patients admitted to hospital with diagnosis of ACS.

Other: Observational registry with no intervention.

Interventions

Observational registry with no intervention. OTHER

No intervention

ACS patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who are admitted to any of the eight general hospitals in Kuwait with a diagnosis of ACS. The sample size will be 10,000 patients. ACS diagnosis includes ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina.

You may qualify if:

• Patient is admitted to hospital with admission diagnosis of ACS.
• Patient or a relative consent to enrolment in the registry.

You may not qualify if:

• Refusal or inability to consent for enrolment

Sponsors & Collaborators

• Gulf Heart Association: lead
• Servier: collaborator
• Sanofi: collaborator
• Beshara company: collaborator
• Kuwait Heart Foundation: collaborator

Study Sites (1)

Mubarak Al Kabeer hospital

Kuwait City, Kuwait, 13110, Kuwait

Location

Study Officials

• Mohammad Zubaid, Professor

  Kuwait University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 2, 2023
• First Posted: May 15, 2023
• Study Start: May 15, 2023
• Primary Completion: November 25, 2024
• Study Completion: June 30, 2025
• Last Updated: August 20, 2025

Record last verified: 2025-03

Locations

KU (1)